Chrubasik Cosima, Roufogalis Basil D, Müller-Ladner Ulf, Chrubasik Sigrun
Department of Forensic Medicine, University of Freiburg, Albertstr. 9, 79104 Freiburg, Germany.
Phytother Res. 2008 Jun;22(6):725-33. doi: 10.1002/ptr.2400.
Rose hip, rose hip and seed and rose hip seed, all were negatively monographed by the German Commission E due to insufficient evidence of effects and effectiveness. Therefore a comprehensive review of the literature was conducted to summarize the pharmacological and clinical effects of Rosa canina L. to reevaluate its usefulness in traditional medicine. For various preparations of rose hip and rose hip and seed, antioxidative and antiinflammatory effects have been demonstrated. Lipophilic constituents are involved in those mechanisms of action. The proprietary rose hip and seed powder Litozin has been employed successfully in a number of exploratory studies in patients suffering from osteoarthritis, rheumatoid arthritis and low back pain. However, the sizes of the clinical effects for the different indications need to be determined to assure clinical significance. There is also a rationale behind the use of Litozin as part of a hypocaloric diet based on the rose hip probiotic, stool regulating and smooth muscle-relaxing actions, as well as the rose hip seed lipid-lowering, antiobese and antiulcerogenic effects. Further research is needed to clarify the importance of the reported promising experimental effects in clinical use and to characterize the optimum rose hip seed oil preparation for topical use in the treatment of skin diseases.
玫瑰果、玫瑰果与种子以及玫瑰果籽，因缺乏药效和有效性的充分证据，均被德国委员会E列入否定性专论。因此，开展了一项文献综述，以总结犬蔷薇的药理和临床作用，重新评估其在传统医学中的效用。对于玫瑰果以及玫瑰果与种子的各种制剂，已证实其具有抗氧化和抗炎作用。亲脂性成分参与了这些作用机制。专利玫瑰果与种子粉Litozin已成功用于多项针对骨关节炎、类风湿性关节炎和腰痛患者的探索性研究。然而，需要确定不同适应症的临床疗效大小，以确保临床意义。基于玫瑰果的益生菌、调节粪便和舒张平滑肌作用，以及玫瑰果籽的降血脂、抗肥胖和抗溃疡作用，将Litozin用作低热量饮食的一部分也有其理论依据。需要进一步研究，以阐明所报道的有前景的实验效果在临床应用中的重要性，并确定用于治疗皮肤病的局部用最佳玫瑰果籽油制剂的特性。
