Sangameswaran B, Jayakar B
Vinayaka Mission's College of Pharmacy, Vinayaka Missions University, Kondappanaickan patty, Salem, 636 008, Tamil Nadu, India.
J Nat Med. 2008 Jan;62(1):79-82. doi: 10.1007/s11418-007-0189-9. Epub 2007 Aug 23.
Anti-diabetic, anti-hyperlipidemic and spermatogenic effects were studies with methanolic extract of stem of Amaranthus spinosus Linn (Family: Amaranthaceae) in diabetic rats. In streptozotocin (STZ)-induced diabetic rats, it was observed that both the standard drug (Glibenclamide) and methanolic extract of Amaranthus spinosus Linn. significantly exhibited control of blood glucose level on a 15 day model. Further, the methanolic extract also showed significant anti-hyperlipidemic and spermatogenic effects in STZ-induced diabetic rats. The methanolic extract has also accelerated the process of spermatogenesis by increasing the sperm count and accessory sex organ weights. The present investigation of the plant established some pharmacological evidence to support the folklore claim that it is used as an anti-diabetic.
采用刺苋（苋科）茎的甲醇提取物对糖尿病大鼠进行了抗糖尿病、抗高脂血症和生精作用的研究。在链脲佐菌素（STZ）诱导的糖尿病大鼠中，观察到标准药物（格列本脲）和刺苋甲醇提取物在15天模型中均能显著控制血糖水平。此外，甲醇提取物在STZ诱导的糖尿病大鼠中还表现出显著的抗高脂血症和生精作用。甲醇提取物还通过增加精子数量和附属生殖器官重量加速了精子发生过程。目前对该植物的研究确立了一些药理学证据，以支持其作为抗糖尿病药物的民间说法。
