三种苋属植物甲醇提取物的抗糖尿病和抗胆固醇活性
Anti-diabetic and anti-cholesterolemic activity of methanol extracts of three species of Amaranthus.
作者信息
Girija K, Lakshman K, Udaya Chandrika, Sabhya Sachi Ghosh, Divya T
机构信息
Department of Pharmacognosy, PES College of Pharmacy, Bangalore-560050, Karnataka, India.
出版信息
Asian Pac J Trop Biomed. 2011 Apr;1(2):133-8. doi: 10.1016/S2221-1691(11)60011-7.
OBJECTIVE
To investigate the anti-diabetic and anti-cholesterolemic activity of methanol extracts of leaves of Amaranthus caudatus, Amaranthus spinosus and Amaranthus viridis in normal and streptozotocin (STZ) induced diabetic rats.
METHODS
In this study, the anti-diabetic and anti-cholesterolemic activity of methanol extracts of leaves of all three plants was evaluated by using normal and STZ induced diabetic rats at a dose of 200 mg/kg and 400 mg/kg p.o. daily for 21 days. Blood glucose levels and body weight were monitored at specific intervals, and different biochemical parameters, serum cholesterol, serum triglyceride, high density lipoprotein, low density lipoprotein and very low density lipoprotein were also assessed in the experimental animals. Histology of pancreas was performed.
RESULTS
It was found that all the three plants at 400 mg/kg dose showed significant anti-diabetic and anti-cholesterolemic activity (P<0.01), while at 200 mg/kg dose less significant anti-diabetic activity (P<0.05) was observed.
CONCLUSIONS
Methanol extracts of Amaranthus caudatus, Amaranthus spinosus and Amaranthus viridis showed significant anti-diabetic and anti-cholesterolemic activity, which provides the scientific proof for their traditional claims.
目的
研究尾穗苋、刺苋和绿穗苋叶片甲醇提取物对正常及链脲佐菌素（STZ）诱导的糖尿病大鼠的抗糖尿病和抗胆固醇活性。
方法
在本研究中，以200mg/kg和400mg/kg的口服剂量，对正常及STZ诱导的糖尿病大鼠每日给药，持续21天，以此评估这三种植物叶片甲醇提取物的抗糖尿病和抗胆固醇活性。在特定时间间隔监测血糖水平和体重，并对实验动物的不同生化参数、血清胆固醇、血清甘油三酯、高密度脂蛋白、低密度脂蛋白和极低密度脂蛋白进行评估。对胰腺进行组织学检查。
结果
发现所有三种植物在400mg/kg剂量时均表现出显著的抗糖尿病和抗胆固醇活性（P<0.01），而在200mg/kg剂量时观察到的抗糖尿病活性较弱（P<0.05）。
结论
尾穗苋、刺苋和绿穗苋的甲醇提取物表现出显著的抗糖尿病和抗胆固醇活性，为它们的传统药用价值提供了科学依据。
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