Hoensch Harald, Groh Bertram, Edler Lutz, Kirch Wilhelm
Marien-hospital Darmstadt, Martinspfad 72, Darmstadt D-64285, Germany.
World J Gastroenterol. 2008 Apr 14;14(14):2187-93. doi: 10.3748/wjg.14.2187.
To investigate biological prevention with flavonoids the recurrence risk of neoplasia was studied in patients with resected colorectal cancer and after adenoma polypectomy.
Eighty-seven patients, 36 patients with resected colon cancer and 51 patients after polypectomy, were divided into 2 groups: one group was treated with a flavonoid mixture (daily standard dose 20 mg apigenin and 20 mg epigallocathechin-gallat, n = 31) and compared with a matched control group (n = 56). Both groups were observed for 3-4 years by surveillance colonoscopy and by questionnaire.
Of 87 patients enrolled in this study, 36 had resected colon cancer and 29 of these patients had surveillance colonoscopy. Among the flavonoid-treated patients with resected colon cancer (n = 14), there was no cancer recurrence and one adenoma developed. In contrast the cancer recurrence rate of the 15 matched untreated controls was 20% (3 of 15) and adenomas evolved in 4 of those patients (27%). The combined recurrence rate for neoplasia was 7% (1 of 14) in the treated patients and 47% (7 of 15) in the controls (P = 0.027).
Sustained long-term treatment with a flavonoid mixture could reduce the recurrence rate of colon neoplasia in patients with resected colon cancer.
为研究黄酮类化合物的生物预防作用，对接受过结直肠癌切除术的患者以及接受过腺瘤息肉切除术后的患者的肿瘤复发风险进行了研究。
87例患者，其中36例为接受过结肠癌切除术的患者，51例为接受过息肉切除术后的患者，被分为两组：一组接受黄酮类化合物混合物治疗（每日标准剂量为20毫克芹菜素和20毫克表没食子儿茶素没食子酸酯，n = 31），并与匹配的对照组（n = 56）进行比较。两组均通过结肠镜监测和问卷调查观察3 - 4年。
在本研究纳入的87例患者中，36例接受过结肠癌切除术，其中29例患者接受了结肠镜监测。在接受黄酮类化合物治疗的结肠癌切除患者中（n = 14），无癌症复发，仅1例出现腺瘤。相比之下，15例匹配的未治疗对照组患者的癌症复发率为20%（15例中有3例），其中4例患者（27%）出现腺瘤进展。治疗组患者的肿瘤综合复发率为7%（14例中有1例），对照组为47%（15例中有7例）（P = 0.027）。
长期持续使用黄酮类化合物混合物治疗可降低接受过结肠癌切除术患者的结肠肿瘤复发率。
