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过程控制与法医应用中新兴的非侵入式拉曼方法。

Emerging non-invasive Raman methods in process control and forensic applications.

作者信息

Macleod Neil A, Matousek Pavel

机构信息

Central Laser Facility, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0QX, UK.

出版信息

Pharm Res. 2008 Oct;25(10):2205-15. doi: 10.1007/s11095-008-9587-2. Epub 2008 Apr 16.

DOI:10.1007/s11095-008-9587-2
PMID:18415048
Abstract

This article reviews emerging Raman techniques (Spatially Offset and Transmission Raman Spectroscopy) for non-invasive, sub-surface probing in process control and forensic applications. New capabilities offered by these methods are discussed and several application examples are given including the non-invasive detection of counterfeit drugs through blister packs and opaque plastic bottles and the rapid quantitative analysis of the bulk content of pharmaceutical tablets and capsules without sub-sampling.

摘要

本文综述了新兴的拉曼技术（空间偏移拉曼光谱和透射拉曼光谱）在过程控制和法医应用中的非侵入性、表面下探测。讨论了这些方法所提供的新功能，并给出了几个应用实例，包括通过泡罩包装和不透明塑料瓶对假药进行非侵入性检测，以及对药片片剂和胶囊的批量含量进行快速定量分析而无需进行子采样。

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Higher-order brain function analysis by trans-cranial dynamic near-infrared spectroscopy imaging.经颅动态近红外光谱成像的高阶脑功能分析
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Characterization of genuine and fake artesunate anti-malarial tablets using Fourier transform infrared imaging and spatially offset Raman spectroscopy through blister packs.通过泡罩包装，利用傅里叶变换红外成像和空间偏移拉曼光谱对正品和假冒青蒿琥酯抗疟药片进行表征。
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Raman signal enhancement in deep spectroscopy of turbid media.浑浊介质深度光谱中的拉曼信号增强
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