超武装糖基供体在化学选择性寡糖合成中的应用。
Application of the superarmed glycosyl donor to chemoselective oligosaccharide synthesis.
作者信息
Mydock Laurel K, Demchenko Alexei V
机构信息
Department of Chemistry and Biochemistry, University of Missouri-St. Louis, St. Louis, Missouri 63121, USA.
出版信息
Org Lett. 2008 Jun 5;10(11):2107-10. doi: 10.1021/ol800648d. Epub 2008 May 1.
Abstract
Recently, we discovered a novel method for "superarming" glycosyl donors. Herein, this concept has been exemplified in one-pot oligosaccharide syntheses, whereby the superarmed glycosyl donor was chemoselectively activated over traditional "armed" and disarmed glycosyl acceptors. Direct side-by-side comparison of the reactivities of the classic armed and superarmed glycosyl donors further validates the credibility of the novel concept.
摘要
最近，我们发现了一种用于“超活化”糖基供体的新方法。在此，这一概念已在一锅法寡糖合成中得到例证，即超活化糖基供体相对于传统的“活化”和“钝化”糖基受体具有化学选择性活化作用。对经典活化糖基供体和超活化糖基供体的反应活性进行直接并列比较，进一步验证了这一新概念的可信度。
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