具有低水平万古霉素耐药性的粪肠球菌N06 - 0364的分子特征分析，该菌株携带一个新的D - 丙氨酸 - D - 丝氨酸基因簇vanL。
Molecular characterization of Enterococcus faecalis N06-0364 with low-level vancomycin resistance harboring a novel D-Ala-D-Ser gene cluster, vanL.
作者信息
Boyd David A, Willey Barbara M, Fawcett Darlene, Gillani Nazira, Mulvey Michael R
机构信息
National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
出版信息
Antimicrob Agents Chemother. 2008 Jul;52(7):2667-72. doi: 10.1128/AAC.01516-07. Epub 2008 May 5.
Abstract
Enterococcus faecalis N06-0364, exhibiting a vancomycin MIC of 8 microg/ml, was found to harbor a novel D-Ala-D-Ser gene cluster, designated vanL. The vanL gene cluster was similar in organization to the vanC operon, but the VanT serine racemase was encoded by two separate genes, vanTm(L) (membrane binding) and vanTr(L) (racemase).
摘要
粪肠球菌N06 - 0364的万古霉素最低抑菌浓度为8微克/毫升，发现其含有一个新的D - 丙氨酸 - D - 丝氨酸基因簇，命名为vanL。vanL基因簇在组织结构上与vanC操纵子相似，但VanT丝氨酸消旋酶由两个独立的基因vanTm(L)（膜结合）和vanTr(L)（消旋酶）编码。
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