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本文引用的文献

1
VanG-type vancomycin-resistant Enterococcus faecalis strains isolated in Canada.在加拿大分离出的VanG型耐万古霉素粪肠球菌菌株。
Antimicrob Agents Chemother. 2006 Jun;50(6):2217-21. doi: 10.1128/AAC.01541-05.
2
Transcriptional analysis of the vanC cluster from Enterococcus gallinarum strains with constitutive and inducible vancomycin resistance.来自具有组成型和诱导型万古霉素耐药性的鹑鸡肠球菌菌株的vanC基因簇的转录分析。
Antimicrob Agents Chemother. 2005 Mar;49(3):1060-6. doi: 10.1128/AAC.49.3.1060-1066.2005.
3
Vancomycin resistance in enterococci due to synthesis of precursors terminating in D-alanyl-D-serine.肠球菌中由于合成以D-丙氨酰-D-丝氨酸结尾的前体而产生的万古霉素耐药性。
Antimicrob Agents Chemother. 2005 Jan;49(1):21-5. doi: 10.1128/AAC.49.1.21-25.2005.
4
Enterococcus faecium N03-0072 carries a new VanD-type vancomycin resistance determinant: characterization of the VanD5 operon.屎肠球菌N03 - 0072携带一种新型VanD型万古霉素耐药决定簇：VanD5操纵子的特性
J Antimicrob Chemother. 2004 Sep;54(3):680-3. doi: 10.1093/jac/dkh391. Epub 2004 Aug 12.
5
The vanG glycopeptide resistance operon from Enterococcus faecalis revisited.粪肠球菌中vanG糖肽抗性操纵子的再探讨。
Mol Microbiol. 2003 Nov;50(3):931-48. doi: 10.1046/j.1365-2958.2003.03737.x.
6
High-throughput TAIL-PCR as a tool to identify DNA flanking insertions.高通量热不对称交错PCR作为鉴定插入侧翼DNA的工具。
Methods Mol Biol. 2003;236:241-72. doi: 10.1385/1-59259-413-1:241.
7
Role of the transmembrane domain of the VanT serine racemase in resistance to vancomycin in Enterococcus gallinarum BM4174.鹑鸡肠球菌BM4174中VanT丝氨酸消旋酶跨膜结构域在对万古霉素耐药中的作用
J Antimicrob Chemother. 2003 Mar;51(3):557-64. doi: 10.1093/jac/dkg128.
8
Molecular characterization of the vanE gene cluster in vancomycin-resistant Enterococcus faecalis N00-410 isolated in Canada.加拿大分离出的耐万古霉素粪肠球菌N00 - 410中vanE基因簇的分子特征分析
Antimicrob Agents Chemother. 2002 Jun;46(6):1977-9. doi: 10.1128/AAC.46.6.1977-1979.2002.
9
Improved primer design for multiplex PCR analysis of vancomycin-resistant Enterococcus spp.用于耐万古霉素肠球菌属多重PCR分析的改进引物设计
J Clin Microbiol. 2001 Jun;39(6):2367-8. doi: 10.1128/JCM.39.6.2367-2368.2001.
10
vanC cluster of vancomycin-resistant Enterococcus gallinarum BM4174.鸡肠球菌BM4174耐万古霉素的vanC基因簇
Antimicrob Agents Chemother. 2000 Jun;44(6):1660-6. doi: 10.1128/AAC.44.6.1660-1666.2000.

具有低水平万古霉素耐药性的粪肠球菌N06 - 0364的分子特征分析，该菌株携带一个新的D - 丙氨酸 - D - 丝氨酸基因簇vanL。

Molecular characterization of Enterococcus faecalis N06-0364 with low-level vancomycin resistance harboring a novel D-Ala-D-Ser gene cluster, vanL.

作者信息

Boyd David A, Willey Barbara M, Fawcett Darlene, Gillani Nazira, Mulvey Michael R

机构信息

National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.

出版信息

Antimicrob Agents Chemother. 2008 Jul;52(7):2667-72. doi: 10.1128/AAC.01516-07. Epub 2008 May 5.

DOI:10.1128/AAC.01516-07
PMID:18458129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2443935/
Abstract

Enterococcus faecalis N06-0364, exhibiting a vancomycin MIC of 8 microg/ml, was found to harbor a novel D-Ala-D-Ser gene cluster, designated vanL. The vanL gene cluster was similar in organization to the vanC operon, but the VanT serine racemase was encoded by two separate genes, vanTm(L) (membrane binding) and vanTr(L) (racemase).

摘要

粪肠球菌N06 - 0364的万古霉素最低抑菌浓度为8微克/毫升，发现其含有一个新的D - 丙氨酸 - D - 丝氨酸基因簇，命名为vanL。vanL基因簇在组织结构上与vanC操纵子相似，但VanT丝氨酸消旋酶由两个独立的基因vanTm(L)（膜结合）和vanTr(L)（消旋酶）编码。