Leese Morven, Schene Aart, Koeter Maarten, Meijer Karin, Bindman Jonathan, Mazzi Mariangela, Puschner Bernd, Burti Lorenzo, Becker Thomas, Moreno Mauricio, Celani Daniela, White Ian R, Thonicroft Graham
Health Services and Population Research Department, Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK.
J Clin Epidemiol. 2008 Jun;61(6):588-96. doi: 10.1016/j.jclinepi.2007.08.004. Epub 2008 Feb 14.
To examine the feasibility and reliability of the Medical Outcomes Study 36 Item Short Form Health Survey (SF-36) for patients with schizophrenia, focusing on the eight scales and various aggregate summary measures.
Secondary analysis of data from the European multicenter QUATRO medication adherence trial and the Regional Psychosis Project from The Netherlands. Methods included exploratory and confirmatory factor analyses and estimation of aggregate score reliability using Cronbach's alpha and Tarkkonen's generalized reliability index. The aggregate scores that were compared included two sets based on factor analyses, the standard "physical and mental health component summary scores" (PCS and MCS) and scores based on the original conceptual model of the SF-36 (simple sum of first four scales for physical health, last four for mental health).
The eight SF-36 scales were feasible to administer and reliable. Factor analyses of the QUATRO baseline scale data suggested two or three factors, the latter solution including a general "role limitation" factor. Aggregate scores based on the conceptual model had the highest generalized reliability of those compared.
SF-36 scales are suitable for patients with schizophrenia. Aggregate scores based on the conceptual model may be preferable to the MCS and PCS for such patients. Further investigation of factor structure is advisable.
探讨医学结局研究简明健康调查问卷（SF - 36）用于精神分裂症患者的可行性和可靠性，重点关注八个分量表及各种综合汇总指标。
对来自欧洲多中心QUATRO药物依从性试验和荷兰地区精神病项目的数据进行二次分析。方法包括探索性和验证性因子分析，以及使用克朗巴赫α系数和塔尔科宁广义可靠性指数估计汇总得分的可靠性。所比较的汇总得分包括基于因子分析的两组得分、标准的“生理和心理健康综合得分”（PCS和MCS）以及基于SF - 36原始概念模型的得分（身体健康前四个量表的简单总和，心理健康后四个量表的简单总和）。
SF - 36的八个分量表易于实施且可靠。QUATRO基线量表数据的因子分析表明存在两个或三个因子，后一种解法包括一个一般的“角色限制”因子。在所比较的汇总得分中，基于概念模型的得分具有最高的广义可靠性。
SF - 36量表适用于精神分裂症患者。对于此类患者，基于概念模型的汇总得分可能比MCS和PCS更可取。建议进一步研究因子结构。
