前列腺素 E(2)、白三烯 B(4)和血小板活化因子对细胞因子基因的调控。
Cytokine gene regulation by PGE(2), LTB(4) and PAF.
机构信息
Immunology Division Department of Pediatrics Faculty of Medicine University of Sherbrooke Sherbrooke QC J1H 5N4 Canada.
出版信息
Mediators Inflamm. 1992;1(1):5-8. doi: 10.1155/S0962935192000024.
Abstract
The initial response of the host to noxious stimuli produces a nonspecific inflammatory response. A more specific immune response is believed to be modulated by two classes of molecules: lipid mediators (PG, LT and PAF) and cytokines, synthesized by phagocytes and parenchyreal cells. In this review we discuss the increasing evidence of the interrelationship between eicosanoids, PAF and cytokines: IL-1 and TNF induce PG synthesis in various cells and PG, in turn, modulate cytokine production. We focused on the regulatory effects of LTB(4), PGE(2) and PAF on cytokine gene expression.
摘要
机体对有害刺激的初始反应会产生非特异性炎症反应。人们认为更为特异的免疫反应受到两类分子的调节：脂类介质（PG、LT 和 PAF）和细胞因子，它们由吞噬细胞和实质细胞合成。在这篇综述中，我们讨论了关于花生四烯酸代谢产物、PAF 和细胞因子之间相互关系的更多证据：IL-1 和 TNF 诱导各种细胞中 PG 的合成，而 PG 又反过来调节细胞因子的产生。我们重点讨论了 LTB(4)、PGE(2) 和 PAF 对细胞因子基因表达的调节作用。
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