Kauffman Douglas R, Star Alexander
Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Chem Soc Rev. 2008 Jun;37(6):1197-206. doi: 10.1039/b709567h. Epub 2008 Apr 7.
The year 2008 marks the 10th anniversary of the carbon nanotube field-effect transistor (NTFET). In the past decade a vast amount of effort has been placed on the development of NTFET based sensors for the detection of both chemical and biological species. Towards this end, NTFETs show great promise because of their extreme environmental sensitivity, small size, and ultra-low power requirements. Despite the great progress NTFETs have shown in the field of biological sensing, debate still exists over the mechanistic origins underlying the electronic response of NTFET devices, specifically whether analyte species interact with the carbon nanotube conduction channel or if interaction with the NTFET electrodes actually triggers device response. In this tutorial review, we describe the fabrication of NTFET devices, and detail several reports that illustrate recent advances in biological detection using NTFET devices, while highlighting the suggested mechanisms explaining the device response to analyte species. In doing this we hope to show that NTFET technology has the potential for low-cost and portable bioanalytical platforms.
2008年是碳纳米管场效应晶体管（NTFET）诞生10周年。在过去十年中，人们投入了大量精力来开发基于NTFET的传感器，用于检测化学和生物物质。为此，NTFET因其极高的环境灵敏度、小尺寸和超低功耗需求而展现出巨大潜力。尽管NTFET在生物传感领域取得了巨大进展，但对于NTFET器件电子响应的机理根源仍存在争议，特别是分析物与碳纳米管传导通道是否相互作用，或者与NTFET电极的相互作用是否实际上触发了器件响应。在本教程综述中，我们描述了NTFET器件的制造，并详细介绍了几篇报告，这些报告阐述了使用NTFET器件进行生物检测的最新进展，同时突出了用于解释器件对分析物响应的推测机制。通过这样做，我们希望表明NTFET技术具有用于低成本和便携式生物分析平台的潜力。
