Leone Maria Cristina, Gori Tommaso, Fineschi Massimo
Department of Internal Cardiovascular and Geriatric Medicine, and U.O.Emodinamica, University of Siena, Siena, Italy.
Clin Hemorheol Microcirc. 2008;39(1-4):185-90.
The coronary slow flow phenomenon (CSFP) is an angiographic finding that is characterised by delayed progression of the contrast medium during coronary angiography. The mechanism of this phenomenon remains unknown. In the present paper, we revise the current evidence regarding this phenomenon and discuss recent findings from our group reporting increased resting resistances in patients with the CSFP. We report that these patients had preserved blood flow responses to the intracoronary infusion of the vasodilator papaverine, demonstrating that the CSFP is not necessarily associated with an abnormal coronary flow reserve. Based on these findings and on the review of the current literature, we concur with the concept proposed by Beltrame et al. that the CSFP should be considered a separate clinical entity. Further studies are necessary to describe the clinical characteristics, including the prognosis, of these patients and to identify potential treatments.
冠状动脉慢血流现象（CSFP）是一种血管造影表现，其特征为冠状动脉造影期间造影剂延迟推进。该现象的机制尚不清楚。在本文中，我们回顾了关于此现象的现有证据，并讨论了我们团队最近的研究结果，这些结果报告了CSFP患者静息阻力增加。我们报告称，这些患者对冠状动脉内注入血管扩张剂罂粟碱的血流反应保持正常，这表明CSFP不一定与异常的冠状动脉血流储备相关。基于这些发现以及对当前文献的综述，我们赞同贝尔特拉梅等人提出的概念，即CSFP应被视为一个独立的临床实体。有必要进行进一步研究以描述这些患者的临床特征，包括预后，并确定潜在的治疗方法。
