• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Alteration of GyrA amino acid required for ciprofloxacin resistance in Klebsiella pneumoniae isolates in China.中国肺炎克雷伯菌分离株中对环丙沙星耐药所需的GyrA氨基酸改变。
Antimicrob Agents Chemother. 2008 Aug;52(8):2980-3. doi: 10.1128/AAC.00151-08. Epub 2008 May 27.
2
Investigation of gyrA and parC mutations and the prevalence of plasmid-mediated quinolone resistance genes in Klebsiella pneumoniae clinical isolates.肺炎克雷伯菌临床分离株中gyrA 和 parC 突变与质粒介导喹诺酮耐药基因流行率的研究。
BMC Microbiol. 2024 Jul 18;24(1):265. doi: 10.1186/s12866-024-03383-5.
3
Prevalence of plasmid-mediated qnr determinants and gyrase alteration in Klebsiella pneumoniae isolated from a university teaching hospital in Malaysia.马来西亚一所教学医院分离的肺炎克雷伯菌中质粒介导的 qnr 决定因子和拓扑异构酶改变的流行情况。
Eur Rev Med Pharmacol Sci. 2013 Jul;17(13):1744-7.
4
The determination of gyrA and parC mutations and the prevalence of plasmid-mediated quinolone resistance genes in carbapenem resistant Klebsiella pneumonia ST11 and ST76 strains isolated from patients in Heilongjiang Province, China.中国黑龙江省患者分离的耐碳青霉烯类肺炎克雷伯菌ST11和ST76菌株中gyrA和parC基因突变的测定及质粒介导喹诺酮耐药基因的流行情况
Infect Genet Evol. 2020 Aug;82:104319. doi: 10.1016/j.meegid.2020.104319. Epub 2020 Apr 8.
5
Specific patterns of gyrA mutations determine the resistance difference to ciprofloxacin and levofloxacin in Klebsiella pneumoniae and Escherichia coli.特定的 gyrA 突变模式决定了肺炎克雷伯菌和大肠埃希菌对环丙沙星和左氧氟沙星的耐药差异。
BMC Infect Dis. 2013 Jan 7;13:8. doi: 10.1186/1471-2334-13-8.
6
Genotypes of Ciprofloxacin-Resistant Klebsiella pneumoniae in Korea and Their Characteristics According to the Genetic Lineages.韩国耐环丙沙星肺炎克雷伯菌的基因型及其按遗传谱系的特征
Microb Drug Resist. 2015 Dec;21(6):622-30. doi: 10.1089/mdr.2015.0001. Epub 2015 Jul 24.
7
Linkage of ciprofloxacin resistance with a single genotypic cluster of Klebsiella pneumoniae.环丙沙星耐药性与肺炎克雷伯菌单一基因型簇的关联。
Int J Antimicrob Agents. 2006 Jan;27(1):73-6. doi: 10.1016/j.ijantimicag.2005.09.007.
8
The comparison of MAMA PCR and SSCP PCR to study chromosomal resistance against Ciprofloxacin and Nalidixic acid in Escherichia coli and Klebsiella pneumoniae.比较 MAMA PCR 和 SSCP PCR 以研究大肠杆菌和肺炎克雷伯菌对环丙沙星和萘啶酸的染色体耐药性。
Microb Pathog. 2018 Jul;120:181-186. doi: 10.1016/j.micpath.2018.05.005. Epub 2018 May 6.
9
Comparative analysis of quinolone resistance in clinical isolates of Klebsiella pneumoniae and Escherichia coli from Chinese children and adults.中国儿童和成人肺炎克雷伯菌及大肠杆菌临床分离株喹诺酮耐药性的比较分析
Biomed Res Int. 2015;2015:168292. doi: 10.1155/2015/168292. Epub 2015 Feb 10.
10
Frequency of DNA gyrase and topoisomerase IV mutations and plasmid-mediated quinolone resistance genes among Escherichia coli and Klebsiella pneumoniae isolated from urinary tract infections in Azerbaijan, Iran.伊朗阿塞拜疆分离的尿路感染大肠埃希菌和肺炎克雷伯菌中 DNA 拓扑异构酶 IV 和拓扑异构酶基因突变及质粒介导喹诺酮耐药基因的频率。
J Glob Antimicrob Resist. 2019 Jun;17:39-43. doi: 10.1016/j.jgar.2018.11.003. Epub 2018 Nov 13.

引用本文的文献

1
Investigation of gyrA and parC mutations and the prevalence of plasmid-mediated quinolone resistance genes in Klebsiella pneumoniae clinical isolates.肺炎克雷伯菌临床分离株中gyrA 和 parC 突变与质粒介导喹诺酮耐药基因流行率的研究。
BMC Microbiol. 2024 Jul 18;24(1):265. doi: 10.1186/s12866-024-03383-5.
2
Clinical and Microbiological Risk Factors for 30-Day Mortality of Bloodstream Infections Caused by OXA-48-Producing .产OXA-48型血流感染30天死亡率的临床和微生物学危险因素
Pathogens. 2023 Dec 21;13(1):11. doi: 10.3390/pathogens13010011.
3
Epidemiology, Environmental Risks, Virulence, and Resistance Determinants of From Dairy Cows in Hubei, China.中国湖北奶牛的流行病学、环境风险、毒力及耐药性决定因素
Front Microbiol. 2022 May 4;13:858799. doi: 10.3389/fmicb.2022.858799. eCollection 2022.
4
Experimental and Molecular Docking Studies of Cyclic Diphenyl Phosphonates as DNA Gyrase Inhibitors for Fluoroquinolone-Resistant Pathogens.环状二苯基膦酸酯作为耐氟喹诺酮病原体的DNA促旋酶抑制剂的实验和分子对接研究
Antibiotics (Basel). 2022 Jan 1;11(1):53. doi: 10.3390/antibiotics11010053.
5
Characterization of Klebsiella pneumoniae associated with cattle infections in southwest China using multi-locus sequence typing (MLST), antibiotic resistance and virulence-associated gene profile analysis.利用多位点序列分型（MLST）、抗生素耐药性和毒力相关基因谱分析对中国西南部与牛感染相关的肺炎克雷伯菌进行特征分析。
Braz J Microbiol. 2018 Nov;49 Suppl 1(Suppl 1):93-100. doi: 10.1016/j.bjm.2018.06.004. Epub 2018 Aug 16.
6
Molecular analysis of ciprofloxacin resistance mechanisms in Malaysian ESBL-producing Klebsiella pneumoniae isolates and development of mismatch amplification mutation assays (MAMA) for rapid detection of gyrA and parC mutations.马来西亚产超广谱β-内酰胺酶肺炎克雷伯菌中环丙沙星耐药机制的分子分析及快速检测gyrA 和 parC 突变的错配扩增突变分析（MAMA）的建立。
Biomed Res Int. 2014;2014:601630. doi: 10.1155/2014/601630. Epub 2014 Apr 10.
7
Comparative analysis of the complete genome of KPC-2-producing Klebsiella pneumoniae Kp13 reveals remarkable genome plasticity and a wide repertoire of virulence and resistance mechanisms.产 KPC-2 肺炎克雷伯菌 Kp13 全基因组的比较分析揭示了其显著的基因组可塑性以及广泛的毒力和耐药机制。
BMC Genomics. 2014 Jan 22;15:54. doi: 10.1186/1471-2164-15-54.
8
Specific patterns of gyrA mutations determine the resistance difference to ciprofloxacin and levofloxacin in Klebsiella pneumoniae and Escherichia coli.特定的 gyrA 突变模式决定了肺炎克雷伯菌和大肠埃希菌对环丙沙星和左氧氟沙星的耐药差异。
BMC Infect Dis. 2013 Jan 7;13:8. doi: 10.1186/1471-2334-13-8.
9
Sequencing and genetic variation of multidrug resistance plasmids in Klebsiella pneumoniae.肺炎克雷伯菌多重耐药质粒的测序和遗传变异。
PLoS One. 2010 Apr 12;5(4):e10141. doi: 10.1371/journal.pone.0010141.

本文引用的文献

1
[Mutations in gyrA and gyrB genes among strains of Gram-negative bacilli isolated from Chilean hospitals and their relation with resistance to fluoroquinolones].[从智利医院分离的革兰氏阴性杆菌菌株中gyrA和gyrB基因的突变及其与对氟喹诺酮类药物耐药性的关系]
Rev Med Chil. 2007 Sep;135(9):1103-10. doi: 10.4067/s0034-98872007000900002. Epub 2007 Nov 15.
2
Changes in qnr prevalence and fluoroquinolone resistance in clinical isolates of Klebsiella pneumoniae and Enterobacter spp. collected from 1990 to 2005.1990年至2005年收集的肺炎克雷伯菌和肠杆菌属临床分离株中qnr流行率和氟喹诺酮耐药性的变化。
Antimicrob Agents Chemother. 2007 Aug;51(8):3001-3. doi: 10.1128/AAC.00256-07. Epub 2007 May 25.
3
Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1.表达质粒携带喹诺酮耐药决定子qnrA1的肠杆菌科细菌对氟喹诺酮类药物的突变预防浓度
Antimicrob Agents Chemother. 2007 Jun;51(6):2236-9. doi: 10.1128/AAC.01444-06. Epub 2007 Apr 2.
4
Differential expression of bla(SHV) related to susceptibility to ampicillin in Klebsiella pneumoniae.
Int J Antimicrob Agents. 2007 Mar;29(3):344-7. doi: 10.1016/j.ijantimicag.2006.10.015. Epub 2007 Feb 2.
5
Antibiotic resistance as a global threat: evidence from China, Kuwait and the United States.抗生素耐药性作为一种全球威胁：来自中国、科威特和美国的证据。
Global Health. 2006 Apr 7;2:6. doi: 10.1186/1744-8603-2-6.
6
Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore.AcrR和ramA在新加坡临床肺炎克雷伯菌分离株对氟喹诺酮耐药中的作用
Antimicrob Agents Chemother. 2003 Sep;47(9):2831-7. doi: 10.1128/AAC.47.9.2831-2837.2003.
7
Patterns of resistance associated with integrons, the extended-spectrum beta-lactamase SHV-5 gene, and a multidrug efflux pump of Klebsiella pneumoniae causing a nosocomial outbreak.与整合子、超广谱β-内酰胺酶SHV-5基因以及导致医院感染暴发的肺炎克雷伯菌多重耐药外排泵相关的耐药模式。
J Clin Microbiol. 2003 Mar;41(3):1161-6. doi: 10.1128/JCM.41.3.1161-1166.2003.
8
Energy-dependent accumulation of norfloxacin and porin expression in clinical isolates of Klebsiella pneumoniae and relationship to extended-spectrum beta-lactamase production.诺氟沙星的能量依赖性积累及肺炎克雷伯菌临床分离株中孔蛋白表达与超广谱β-内酰胺酶产生的关系
Antimicrob Agents Chemother. 2002 Dec;46(12):3926-32. doi: 10.1128/AAC.46.12.3926-3932.2002.
9
Increase in MICs of ciprofloxacin in vivo in two closely related clinical isolates of Enterobacter cloacae.在阴沟肠杆菌的两个密切相关临床分离株中，环丙沙星在体内的最低抑菌浓度增加。
J Antimicrob Chemother. 2002 Apr;49(4):625-30. doi: 10.1093/jac/49.4.625.
10
Phylogenetic diversity of Klebsiella pneumoniae and Klebsiella oxytoca clinical isolates revealed by randomly amplified polymorphic DNA, gyrA and parC genes sequencing and automated ribotyping.通过随机扩增多态性DNA、gyrA和parC基因测序以及自动核糖体分型揭示的肺炎克雷伯菌和产酸克雷伯菌临床分离株的系统发育多样性。
Int J Syst Evol Microbiol. 2001 May;51(Pt 3):915-924. doi: 10.1099/00207713-51-3-915.

中国肺炎克雷伯菌分离株中对环丙沙星耐药所需的GyrA氨基酸改变。

Alteration of GyrA amino acid required for ciprofloxacin resistance in Klebsiella pneumoniae isolates in China.

作者信息

Fu Yingmei, Guo Lishuang, Xu Yan, Zhang Wenli, Gu Jiaao, Xu Jianfeng, Chen Xiaobei, Zhao Yuehui, Ma Jiayu, Liu Xinghan, Zhang Fengmin

机构信息

Department of Medical Microbiology, Harbin Medical University, Pathogenic Biology Key Laboratory of Heilongjiang Province, 194 Xue Fu Road, Harbin 150086, China.

出版信息

Antimicrob Agents Chemother. 2008 Aug;52(8):2980-3. doi: 10.1128/AAC.00151-08. Epub 2008 May 27.

DOI:10.1128/AAC.00151-08
PMID:18505849
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2493132/
Abstract

Resistance to ciprofloxacin was detected in 111 (48.1%) isolates of Klebsiella pneumoniae from China. GyrA alterations were identified in the ciprofloxacin-resistant and ciprofloxacin-susceptible isolates. The results, including previously published data, indicate that the single substitution Ser83-->Ile and three types of double mutations at Ser83 and Asp87 were required for ciprofloxacin resistance (P < 0.05).

摘要

在中国分离出的111株肺炎克雷伯菌（占48.1%）中检测到对环丙沙星的耐药性。在对环丙沙星耐药和敏感的分离株中均鉴定出GyrA改变。这些结果，包括先前发表的数据，表明环丙沙星耐药需要Ser83→Ile的单取代以及Ser83和Asp87处的三种双突变类型（P<0.05）。