中国肺炎克雷伯菌分离株中对环丙沙星耐药所需的GyrA氨基酸改变。
Alteration of GyrA amino acid required for ciprofloxacin resistance in Klebsiella pneumoniae isolates in China.
作者信息
Fu Yingmei, Guo Lishuang, Xu Yan, Zhang Wenli, Gu Jiaao, Xu Jianfeng, Chen Xiaobei, Zhao Yuehui, Ma Jiayu, Liu Xinghan, Zhang Fengmin
机构信息
Department of Medical Microbiology, Harbin Medical University, Pathogenic Biology Key Laboratory of Heilongjiang Province, 194 Xue Fu Road, Harbin 150086, China.
出版信息
Antimicrob Agents Chemother. 2008 Aug;52(8):2980-3. doi: 10.1128/AAC.00151-08. Epub 2008 May 27.
Abstract
Resistance to ciprofloxacin was detected in 111 (48.1%) isolates of Klebsiella pneumoniae from China. GyrA alterations were identified in the ciprofloxacin-resistant and ciprofloxacin-susceptible isolates. The results, including previously published data, indicate that the single substitution Ser83-->Ile and three types of double mutations at Ser83 and Asp87 were required for ciprofloxacin resistance (P < 0.05).
摘要
在中国分离出的111株肺炎克雷伯菌（占48.1%）中检测到对环丙沙星的耐药性。在对环丙沙星耐药和敏感的分离株中均鉴定出GyrA改变。这些结果，包括先前发表的数据，表明环丙沙星耐药需要Ser83→Ile的单取代以及Ser83和Asp87处的三种双突变类型（P<0.05）。
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