Meijer Lisethe, Weiss Jana, Van Velzen Martin, Brouwer Abraham, Bergman Ake, Sauer Pieter J J
Beatrix Children's Hospital, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
Environ Sci Technol. 2008 May 1;42(9):3428-33. doi: 10.1021/es702446p.
As part of a large European Union (EU)-funded comparative toxicology and human epidemiology study, EU-Compare, a selection of organohalogen compounds (OHCs) was analyzed in maternal serum, collected at the 35th week of pregnancy, and in cord serum of a number of their infants to determine maternal concentrations and to investigate the extent of transplacental transfer of these compounds. Eight neutral OHCs were analyzed: one polychlorinated biphenyl (PCB: CB-153),4,4'-DDE, five polybrominated diphenyl ethers (PBDEs: BDE-47, BDE-99, BDE-100, BDE-153, and BDE-154), and hexabromocyclododecane (HBCDD). Five phenolic OHCs were analyzed: three hydroxylated PCBs (40H-CB-107, 40H-CB-146, and 40H-CB-187), one hydroxylated PBDE (60H-BDE-47), and pentachlorophenol (PCP). All OHCs, except 60H-BDE-47, were present in maternal and cord serum. The historically identified OHCs showed the highest concentration: 4,4'-DDE (median value 89 ng/g lipid in maternal serum and 68 ng/g lipid in cord serum) and PCP (median value 970 pg/g serum in maternal serum and 1500 pg/g serum in cord serum). HBCDD and the PBDEs were present at much lower concentrations. We conclude that OHCs are present in the serum of pregnant women, and all compounds tested are transferred over the placenta. Because transfer is occurring at a critical stage of infant development, investigation of the health impact is urgent.
作为一项由欧盟资助的大型比较毒理学和人类流行病学研究（EU-Compare）的一部分，对一系列有机卤素化合物（OHCs）进行了分析。这些化合物取自怀孕35周时采集的孕妇血清及其部分婴儿的脐带血清，目的是确定母体中的浓度，并研究这些化合物的胎盘转移程度。分析了8种中性OHCs：一种多氯联苯（PCB：CB-153）、4,4'-二氯二苯二氯乙烯（4,4'-DDE）、5种多溴二苯醚（PBDEs：BDE-47、BDE-99、BDE-100、BDE-153和BDE-154）以及六溴环十二烷（HBCDD）。还分析了5种酚类OHCs：3种羟基化多氯联苯（4-OH-CB-107、4-OH-CB-146和4-OH-CB-187）、1种羟基化多溴二苯醚（6-OH-BDE-47）和五氯苯酚（PCP）。除6-OH-BDE-47外，所有OHCs均存在于孕妇血清和脐带血清中。历史上已确认的OHCs浓度最高：4,4'-DDE（孕妇血清中脂质中位数为89 ng/g，脐带血清中脂质中位数为68 ng/g）和PCP（孕妇血清中中位数为970 pg/g血清，脐带血清中为1500 pg/g血清）。HBCDD和多溴二苯醚的浓度要低得多。我们得出结论，OHCs存在于孕妇血清中，且所有测试化合物均可通过胎盘转移。由于这种转移发生在婴儿发育的关键阶段，因此迫切需要调查其对健康的影响。
