Battafarano D F, Jefferies B, McAllister C K, Kelly J W
Department of Medicine, Brooke Army Medical Center, Fort Sam Houston, TX 78234-6200.
Mil Med. 1991 Jun;156(6):283-5.
The Ramco latex agglutination test in the diagnosis of systemic candidiasis was utilized for 11 serum samples from 10 patients with systemic candidiasis, 21 serum samples from patients colonized with Candida species, and 20 control serum samples from patients with stable medical problems and no evidence of Candida albicans infection. This study was double-blind and the results of the latex agglutination test did not influence the decision for antifungal therapy. Nine of 10 patients with systemic candidiasis had positive titers (greater than or equal to 1:4); however, these were determined only 1 to 5 days before culture positivity. Nine of 21 (43%) of colonized patients were falsely positive (greater than or equal to 1:4) and all of the control samples were negative. The Ramco latex agglutination test was unreliable and inconsistent in this small sample group to establish an early diagnosis of systemic candidiasis.
Ramco乳胶凝集试验用于诊断系统性念珠菌病，对10例系统性念珠菌病患者的11份血清样本、念珠菌定植患者的21份血清样本以及患有稳定疾病且无白色念珠菌感染证据的20份对照血清样本进行了检测。本研究为双盲研究，乳胶凝集试验结果不影响抗真菌治疗的决策。10例系统性念珠菌病患者中有9例滴度呈阳性（大于或等于1:4）；然而，这些结果是在培养阳性前1至5天确定的。21例定植患者中有9例（43%）出现假阳性（大于或等于1:4），所有对照样本均为阴性。在这个小样本组中，Ramco乳胶凝集试验在早期诊断系统性念珠菌病方面不可靠且不一致。
