Burnie J P, Williams J D
Eur J Clin Microbiol. 1985 Apr;4(2):98-101. doi: 10.1007/BF02013571.
The value of the Ramco latex agglutination test in the diagnosis of systemic candidiasis was determined using 225 serum samples from 30 patients with systemic candidiasis, 81 serum samples from patients colonized with Candida albicans and 400 control serum samples from hospital patients with no evidence of Candida albicans infection. Results were positive (titres greater than or equal to 1:4) in 20 of the patients with systemic candidiasis; ten had titres of 1:8. Only one of the 81 sera from colonized patients was positive (titre greater than 1:4); this serum came from a patient with colonization of the intravenous catheter. No positive results (titres greater than 1:2) were obtained in the control sera once rheumatoid factor was excluded. The test reliably differentiated between colonization and systemic infection but failed to detect some cases of systemic infection. A poor detection rate was seen in cases where only one serum sample was taken. The importance of taking daily serum samples for continuous monitoring is emphasised. Rheumatoid factor positivity and intravenous line colonization should be excluded when interpreting a result.
使用来自30例系统性念珠菌病患者的225份血清样本、来自白色念珠菌定植患者的81份血清样本以及来自无白色念珠菌感染证据的住院患者的400份对照血清样本，确定了Ramco乳胶凝集试验在系统性念珠菌病诊断中的价值。系统性念珠菌病患者中有20例结果呈阳性（滴度大于或等于1:4）；10例滴度为1:8。来自定植患者的81份血清中只有1份呈阳性（滴度大于1:4）；该血清来自一名静脉导管定植患者。排除类风湿因子后，对照血清未获得阳性结果（滴度大于1:2）。该试验能够可靠地区分定植和系统性感染，但未能检测到一些系统性感染病例。在仅采集一份血清样本的情况下，检测率较低。强调了每日采集血清样本进行连续监测的重要性。在解释结果时应排除类风湿因子阳性和静脉导管定植情况。
