“唯有变化才是永恒”：剪接体动力学与剪接调控
"Nought may endure but mutability": spliceosome dynamics and the regulation of splicing.
作者信息
Smith Duncan J, Query Charles C, Konarska Maria M
机构信息
The Rockefeller University, New York, NY 10065, USA.
出版信息
Mol Cell. 2008 Jun 20;30(6):657-66. doi: 10.1016/j.molcel.2008.04.013.
Abstract
The spliceosome is both compositionally and conformationally dynamic. Each transition along the splicing pathway presents an opportunity for progression, pausing, or discard, allowing splice site choice to be regulated throughout both the assembly and catalytic phases of the reaction.
摘要
剪接体在组成和构象上都是动态的。沿着剪接途径的每一次转变都为进展、暂停或舍弃提供了机会，使得剪接位点的选择在反应的组装和催化阶段都能得到调控。
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