Liu Li-Ying, Dong Fang-Tian, Li Hui
Department of Ophthalmology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2007 Dec;29(6):797-802.
To explore the relationship between the classification and degree of diabetic macular edema (DME) and the stages of diabetic retinopathy (DR), diabetic duration, classification of diabetes, use of insulin, and visual loss.
We retrospectively analyzed the stages of DR, diabetic duration, classification of diabetes, use of insulin, and visual loss in 1 172 DR patients with fundus fluorescein angiography (FFA). The occurrence of DME in DR in each stage and the relationships between its related factors were analyzed.
In 1 172 patients, 633 eyes in 394 patients had DME (33.62%), including 265 (41.86%) with focal DME and 368 (58.14%) with diffuse DME. There were 246 (38.86%) eyes with mild DME, 189 (29.86%) with moderate DME, and 198 (31.28%) with severe DME. Significant correlations exhisted among the classification of DME (r = 0.975, P = 0.025), the degree of DME (r = 1.000, P = 0.000), and the stage of DR. DME deteriorated with the increase of the stages of DR. The visual loss significantly correlated with the degree of DME (r = -0.984, P = 0.003). The visual acuity was lower in patients with diffuse DME than those with focal DME. The diabetic duration significantly correlated with the classification and degree of DME (r = 0.962, P = 0.009). DME was mostly seen in patients with a disease course of six years or longer, and its severity and incidence increased along with the prolonged period. Also, The incidence of DME increased in patients with type 2 diabetes and patients who used insulin.
The classification and degree of DME correlates with the stages of DR, diabetic duration, the classification of diabetes, the use of insulin, and visual loss.
探讨糖尿病性黄斑水肿（DME）的分级和程度与糖尿病视网膜病变（DR）分期、糖尿病病程、糖尿病分类、胰岛素使用情况及视力丧失之间的关系。
我们回顾性分析了1172例接受眼底荧光血管造影（FFA）检查的DR患者的DR分期、糖尿病病程、糖尿病分类、胰岛素使用情况及视力丧失情况。分析了各阶段DR中DME的发生情况及其相关因素之间的关系。
在1172例患者中，394例患者的633只眼发生了DME（33.62%），其中265只眼（41.86%）为局灶性DME，368只眼（58.14%）为弥漫性DME。轻度DME患者有246只眼（38.86%），中度DME患者有189只眼（29.86%），重度DME患者有198只眼（31.28%）。DME分级（r = 0.975，P = 0.025）、DME程度（r = 1.000，P = 0.000）与DR分期之间存在显著相关性。DME随DR分期的增加而恶化。视力丧失与DME程度显著相关（r = -0.984，P = 0.003）。弥漫性DME患者的视力低于局灶性DME患者。糖尿病病程与DME分级和程度显著相关（r = 0.962，P = 0.009）。DME多见于病程6年及以上的患者，其严重程度和发病率随病程延长而增加。此外，2型糖尿病患者和使用胰岛素的患者中DME的发病率增加。
DME的分级和程度与DR分期、糖尿病病程、糖尿病分类、胰岛素使用情况及视力丧失相关。
