Ran Yuping, He Xiaodan, Zhang Hao, Dai Yaling, Li Lina, Bulmer G S
Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, P. R. China.
Med Mycol. 2008 Sep;46(6):611-4. doi: 10.1080/13693780802140931.
This is a case of seborrheic dermatitis (SD) barbae from which Malassezia furfur (M. furfur) was isolated. The patient was a 57-year-old Dutch male, who was hospitalized for fever and weakness of extremities. He presented with symmetrical erythema with an abundance of greasy chaffy scales on his beard area. No reasons were detected for his fever following a routine search. M. furfur was identified through mycological examination, including direct microscopic examination, culture, Tween test, esculine splitting test and DNA sequencing, of samples from the skin lesions. The patient was treated with oral itraconazole capsules (200 mg, b.i.d. for 8 days, then 200 mg o.d. for 13 days), washing his scalp and face with 2% ketoconazole shampoo (once a day) and topical application of a cream containing 1% naftifine hydrochloride and 0.25% ketoconazole (b.i.d.). After treatment the fever subsided and the SD lesion gradually healed. M. furfur was not isolated again from skin scrapings and 7 days later therapy was terminated and no recurrence was noted after one week follow-up since the cessation of treatment.
这是一例从胡须部位分离出糠秕马拉色菌的须部脂溢性皮炎病例。患者为一名57岁的荷兰男性，因发热和四肢无力入院。他的胡须部位出现对称性红斑，伴有大量油腻性糠状鳞屑。常规检查未发现其发热原因。通过对皮肤病变样本进行真菌学检查，包括直接显微镜检查、培养、吐温试验、七叶苷分解试验和DNA测序，鉴定出糠秕马拉色菌。患者接受口服伊曲康唑胶囊治疗（200毫克，每日两次，共8天，然后200毫克每日一次，共13天），用2%酮康唑洗发水清洗头皮和面部（每天一次），并局部涂抹含1%盐酸萘替芬和0.25%酮康唑的乳膏（每日两次）。治疗后发热消退，脂溢性皮炎病变逐渐愈合。皮肤刮屑未再次分离出糠秕马拉色菌，7天后停止治疗，治疗停止后随访一周未发现复发。
