Kostereva N, Hofmann M-C
Department of Veterinary Biosciences, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA.
Reprod Domest Anim. 2008 Jul;43 Suppl 2(Suppl 2):386-92. doi: 10.1111/j.1439-0531.2008.01189.x.
Spermatogonial stem cells (SSCs) reside within specialized microenvironments called 'niches', which are essential for their maintenance and self-renewal. In the mammalian testis, the main components of the niche include the Sertoli cell, the growth factors that this nursing cell produces, the basement membrane, and stimuli from the vascular network between the seminiferous tubules. This review focuses on signalling pathways maintaining SSCs self-renewal and differentiation and describes potential mechanisms of regulation of the spermatogonial stem cell niche.
精原干细胞（SSCs）存在于被称为“龛”的特殊微环境中，这对其维持和自我更新至关重要。在哺乳动物睾丸中，龛的主要组成部分包括支持细胞、该滋养细胞产生的生长因子、基底膜以及来自生精小管之间血管网络的刺激。本综述重点关注维持SSCs自我更新和分化的信号通路，并描述精原干细胞龛的潜在调控机制。
