用于成像组织中纳摩尔浓度磁性纳米颗粒的相分辨磁驱动光学相干断层扫描技术。
Phase-resolved magnetomotive OCT for imaging nanomolar concentrations of magnetic nanoparticles in tissues.
作者信息
Oldenburg Amy L, Crecea Vasilica, Rinne Stephanie A, Boppart Stephen A
机构信息
Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
出版信息
Opt Express. 2008 Jul 21;16(15):11525-39.
Abstract
Magnetic nanoparticles (MNPs) are increasingly important in magnetic resonance and biomedical optical imaging. We describe a method for imaging MNPs by detecting nanoscale displacements using a phase-resolved spectral-domain optical coherence tomography (OCT) system. Biological tissues and phantoms are exposed to approximately 800 G magnetic fields modulated at 56 and 100 Hz to mechanically actuate embedded iron oxide MNPs (approximately 20 nm diameter). Sensitivity to 27 microg/g (approximately 2 nM) MNPs within tissue phantoms is achieved by filtering paramagnetic from diamagnetic vibrations. We demonstrate biological feasibility by imaging topically applied MNPs during their diffusion into an excised rat tumor over a 2 hour time period.
摘要
磁性纳米颗粒（MNPs）在磁共振和生物医学光学成像中越来越重要。我们描述了一种通过使用相分辨光谱域光学相干断层扫描（OCT）系统检测纳米级位移来对MNPs进行成像的方法。将生物组织和体模暴露于以56和100Hz调制的约800G磁场中，以机械驱动嵌入的氧化铁MNPs（直径约20nm）。通过从抗磁性振动中过滤顺磁性，实现了对组织体模中27μg/g（约2nM）MNPs的灵敏度。我们通过在2小时的时间段内对局部应用的MNPs扩散到切除的大鼠肿瘤中的过程进行成像，证明了其生物学可行性。
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