造血微环境与骨骼相遇。
Hematopoietic niche and bone meet.
作者信息
Frisch Benjamin J, Porter Rebecca L, Calvi Laura M
机构信息
Endocrine Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.
出版信息
Curr Opin Support Palliat Care. 2008 Sep;2(3):211-7. doi: 10.1097/SPC.0b013e32830d5c12.
PURPOSE OF REVIEW
To provide an overview of the hematopoietic stem cell (HSC) niche in the bone marrow. In addition to highlighting recent advances in the field, we will also discuss components of the niche that may contribute to the development of cancer, or cancer metastases to the bone.
RECENT FINDINGS
Much progress has been very recently made in the understanding of the cellular and molecular interactions in the HSC microenvironment. These recent findings point out the extraordinary complexity of the HSC microenvironment. Emerging data also suggest convergence of signals important for HSC and for leukemia or metastatic disease support.
SUMMARY
The HSC niche comprises complex interactions between multiple cell types and molecules requiring cell-cell signaling as well as local secretion. These components can be thought of as therapeutic targets not only for HSC expansion, but also to modify behavior of hematopoietic malignancies and cancer metastases to the bone.
综述目的
概述骨髓中的造血干细胞（HSC）微环境。除了强调该领域的最新进展外，我们还将讨论可能促成癌症发展或癌症转移至骨的微环境组成部分。
最新发现
最近在理解HSC微环境中的细胞和分子相互作用方面取得了很大进展。这些最新发现指出了HSC微环境的非凡复杂性。新出现的数据还表明，对HSC以及白血病或转移性疾病支持至关重要的信号存在趋同现象。
总结
HSC微环境包括多种细胞类型和分子之间的复杂相互作用，需要细胞间信号传导以及局部分泌。这些组成部分不仅可被视为促进HSC扩增的治疗靶点，还可用于改变造血系统恶性肿瘤的行为以及癌症向骨的转移。
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