Beauchesne Marie-France, Julien Marcel, Julien Louis-André, Piquette Dominique, Forget Amélie, Labrecque Manon, Blais Lucie
Faculty of Pharmacy, University of Montreal, Montreal, Québec, Canada.
Int J Chron Obstruct Pulmon Dis. 2008;3(2):319-22. doi: 10.2147/copd.s2624.
This study was conducted to describe the different antibiotics that are used in the home management of chronic obstructive pulmonary disease (COPD) exacerbations and to estimate the failure rates following the initiation of the antibiotic.
A cohort study was conducted. Patients enrolled in a COPD home management program were included in the analysis. Failure rates were defined as an additional prescription of an antibiotic, an emergency room visit, or a hospitalization for a COPD exacerbation in the 30 days following the initiation of the antibiotic.
A total of 1180 episodes of antibiotic treatment were analyzed. Overall, 348 episodes led to a failure (29.5%). The most frequently used antibiotics were cefuroxime (45.9%) and ciprofloxacin (21.1%).
This project demonstrates that a wide range of antibiotics were prescribed to our population of COPD patients with a moderate to severe form of the disease. Many treatment failures (about 30%) occurred in the 30-day period following the initiation of the home therapy with an antibiotic. Clinicians should be aware of this high failure rate when managing mild exacerbations of COPD at home.
本研究旨在描述慢性阻塞性肺疾病（COPD）加重期居家治疗中使用的不同抗生素，并评估开始使用抗生素后的治疗失败率。
进行了一项队列研究。纳入参加COPD居家管理项目的患者进行分析。治疗失败率定义为开始使用抗生素后30天内额外开具抗生素处方、因COPD加重而急诊就诊或住院治疗。
共分析了1180次抗生素治疗事件。总体而言，348次治疗失败（29.5%）。最常用的抗生素是头孢呋辛（45.9%）和环丙沙星（21.1%）。
该项目表明，我们为患有中度至重度COPD的患者群体开具了多种抗生素。在家中开始使用抗生素治疗后的30天内发生了许多治疗失败情况（约30%）。临床医生在家中处理COPD轻度加重时应意识到这一高失败率。
