Gasiorowska Anita, Poh Choo Hean, Fass Ronnie
Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System, University of Arizona, GI Section (1-111G-1), Tucson, AZ 85723-0001, USA.
Dig Dis Sci. 2009 Sep;54(9):1829-34. doi: 10.1007/s10620-008-0594-2. Epub 2008 Dec 10.
Up to 79% of IBS patients report gastroesophageal reflux disease (GERD) symptoms, and up to 71% of GERD patients report irritable bowel syndrome (IBS) symptoms. There are two principal hypotheses for the common presence of IBS symptoms in GERD patients. The first theory suggests that GERD and IBS overlap in a significant number of patients. The second theory suggests that IBS-like symptoms are part of the spectrum of GERD manifestation. The first theory is supported by genetic studies and similarities in gastrointestinal sensory-motor abnormalities potentially due to general gastrointestinal disorder of smooth muscle or sensory afferents. The other theory is primarily supported by studies demonstrating improvement of IBS-like symptoms in GERD patients receiving anti-reflux treatment. The close relationship between GERD and IBS could be explained by either GERD affecting different levels of the GI tract or a high overlap rate between GERD and IBS due to similar underlying GI dysfunction.
高达79%的肠易激综合征（IBS）患者报告有胃食管反流病（GERD）症状，高达71%的胃食管反流病患者报告有肠易激综合征（IBS）症状。关于胃食管反流病患者中肠易激综合征症状普遍存在的情况，有两种主要假说。第一种理论认为，大量患者中胃食管反流病和肠易激综合征存在重叠。第二种理论认为，类似肠易激综合征的症状是胃食管反流病表现谱的一部分。第一种理论得到了遗传学研究以及胃肠道感觉运动异常相似性的支持，这些异常可能是由于平滑肌或感觉传入神经的一般胃肠道疾病所致。另一种理论主要得到了一些研究的支持，这些研究表明接受抗反流治疗的胃食管反流病患者中类似肠易激综合征的症状有所改善。胃食管反流病和肠易激综合征之间的密切关系可以通过胃食管反流病影响胃肠道的不同层面来解释，或者是由于相似的潜在胃肠道功能障碍导致胃食管反流病和肠易激综合征之间的高重叠率来解释。
