Ramos A, Ley L, Muñez E, Videl A, Sánchez I
Department of Internal Medicine (Infectious Diseases Unit), Spanish Network for Research in Infectious Disease, Hospital Universitario Puerta de Hierro, Universidad Autónoma de Madrid, San Martin de Porres no 4, Madrid, Spain.
Infection. 2009 Aug;37(4):365-7. doi: 10.1007/s15010-008-7364-0. Epub 2008 Aug 25.
Panton-Valentine leukocidin (PVL) is a cytotoxin produced by Staphylococcus aureus that exhibits highly specific lytic activity against polymorphonuclear cells, monocytes, and macrophages. A 34-year-old man admitted for right parietal brain abscess and thickened dura mater in close proximity to a lytic bone lesion is presented. The abscess culture yielded methicillin-sensitive S. aureus that produced PVL. The patient did well after surgery and antibiotic treatment. A hematogenous infection, route of bone infection with progression to dura mater and brain parenchyma was hypothesized. To our knowledge this is the first reported case of a brain abscess due to PVL-positive S. aureus.
杀白细胞素（PVL）是一种由金黄色葡萄球菌产生的细胞毒素，对多形核细胞、单核细胞和巨噬细胞具有高度特异性的溶解活性。本文介绍了一名34岁男性患者，因右顶叶脑脓肿和靠近溶骨性骨病变处的硬脑膜增厚入院。脓肿培养分离出产PVL的甲氧西林敏感金黄色葡萄球菌。患者术后经抗生素治疗恢复良好。推测其感染途径为血源性感染，从骨骼感染发展至硬脑膜和脑实质。据我们所知，这是首例因产PVL金黄色葡萄球菌引起脑脓肿的报道。
