Tatsukawa Yoshimi, Nakashima Eiji, Yamada Michiko, Funamoto Sachiyo, Hida Ayumi, Akahoshi Masazumi, Sakata Ritsu, Ross Norman P, Kasagi Fumiyoshi, Fujiwara Saeko, Shore Roy E
Department of Clinical Studies, Radiation Effects Research Foundation, Hiroshima, Japan.
Radiat Res. 2008 Sep;170(3):269-74. doi: 10.1667/RR1434.1.
Given the well-documented association of in utero radiation exposure with childhood cancer and developmental impairments, the possibility of effects on adult onset diseases is an important issue. The objectives of the present study were to examine the effects of atomic bomb radiation dose on the incidence of hypertension, hypercholesterolemia and cardiovascular disease (myocardial infarction and stroke) among survivors exposed in utero and to compare their risk estimates with those of survivors exposed in childhood (<10 years old) at the time of the bombing. A total of 506 participants exposed in utero and 1,053 participants exposed in childhood were followed during 1978-2003 with biennial clinical examinations. There were no significant radiation dose effects for any diseases in the entire in utero-exposed cohort or in trimester-of-exposure subgroups, though there was a suggestion of an increased risk when fatal and nonfatal cardiovascular disease cases were combined. Positive radiation dose effects were found for hypertension and cardiovascular disease in the childhood-exposure cohort, but there were no statistically significant differences in the relative risks when we compared the two cohorts. Since the in utero cohort was under age 60 at the latest examination, continued follow-up is needed to document cardiovascular disease risk more fully.
鉴于子宫内辐射暴露与儿童癌症和发育障碍之间已得到充分记录的关联，对成人期疾病产生影响的可能性是一个重要问题。本研究的目的是检查原子弹辐射剂量对子宫内暴露幸存者中高血压、高胆固醇血症和心血管疾病（心肌梗死和中风）发病率的影响，并将他们的风险估计与爆炸时儿童期（<10岁）暴露的幸存者进行比较。在1978年至2003年期间，对总共506名子宫内暴露的参与者和1053名儿童期暴露的参与者进行了每两年一次的临床检查随访。在整个子宫内暴露队列或暴露孕期亚组中，任何疾病均未发现明显的辐射剂量效应，不过当致命和非致命心血管疾病病例合并时，有风险增加的迹象。在儿童期暴露队列中发现了高血压和心血管疾病的阳性辐射剂量效应，但在比较两个队列时，相对风险没有统计学上的显著差异。由于在最近一次检查时，子宫内暴露队列的年龄在60岁以下，因此需要继续随访以更全面地记录心血管疾病风险。
