百日咳博德特氏菌疫苗对小鼠绵羊红细胞的佐剂效应：通过皮下注射佐剂和抗原增强细胞介导的免疫。
Adjuvant effect of Bordetella pertussis vaccine to sheep erythrocytes in mice: enhancement of cell-mediated immunity by subcutaneous administration of adjuvant and antigen.
作者信息
Athanassiades T J
出版信息
Infect Immun. 1977 Nov;18(2):416-23. doi: 10.1128/iai.18.2.416-423.1977.
Abstract
The subcutaneous route (s.c.) was used to study the adjuvant effect of Bordetella pertussis vaccine (PV) on cell-mediated immunity to sheep erythorcytes (SRBC). The immune response was measured by a sensitive assay procedure in which the antigen is injected intracutaneously into the mouse ear and the inflammatory swelling is measured with calipers. PV significantly enhanced cell-mediated immunity to SRBC, and the enhancement persisted for at least 3 weeks. PV administered up to 6 days before SRBC also significantly enhanced the response; PV injected 1 or more days after SRBC was not effective. In addition, it was found that PV per se released into the suspension medium a cell-free component(s) (pertussis supernatant) that contributed significantly to adjuvanticity. The adjuvanticity of both PV and PS was completely eliminated by heat.
摘要
采用皮下注射途径（s.c.）研究百日咳博德特氏菌疫苗（PV）对针对绵羊红细胞（SRBC）的细胞介导免疫的佐剂效应。通过一种灵敏的检测程序来测定免疫反应，该程序是将抗原皮内注射到小鼠耳部，并用卡尺测量炎性肿胀。PV显著增强了针对SRBC的细胞介导免疫，且这种增强作用持续至少3周。在注射SRBC前6天内给予PV也能显著增强反应；在注射SRBC后1天或更长时间注射PV则无效。此外，发现PV本身会向悬浮培养基中释放一种无细胞成分（百日咳上清液），该成分对佐剂性有显著贡献。PV和PS的佐剂性均通过加热被完全消除。
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Adjuvant effect of Bordetella pertussis vaccine to sheep erythrocytes in mice: enhancement of cell-mediated immunity by subcutaneous administration of adjuvant and antigen.百日咳博德特氏菌疫苗对小鼠绵羊红细胞的佐剂效应：通过皮下注射佐剂和抗原增强细胞介导的免疫。
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本文引用的文献
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Hyperacute allergic encephalomyelitis: adjuvant effect of pertussis vaccines and extracts.超急性变应性脑脊髓炎：百日咳疫苗及提取物的佐剂作用
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The effect of pertussis vaccine on the immune response of mice to sheep red blood cells.百日咳疫苗对小鼠针对绵羊红细胞免疫反应的影响。
Clin Exp Immunol. 1970 Dec;7(6):817-31.
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Immunopotentiation with BCG. II. Modulation of the response to sheep red blood cells.卡介苗免疫增强作用。II. 对绵羊红细胞反应的调节
J Natl Cancer Inst. 1973 Nov;51(5):1669-76. doi: 10.1093/jnci/51.5.1669.
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