Britton T C, Meyer B U, Benecke R
Department of Neurology, University of Düsseldorf, Germany.
J Neurol Neurosurg Psychiatry. 1991 Jun;54(6):505-10. doi: 10.1136/jnnp.54.6.505.
Central motor pathways were investigated in three patients with congenital mirror movements using magnetic motor cortex stimulation. Response thresholds, amplitudes and latencies were normal. The projection of the corticomotoneuronal pathways was assessed by placing the coil over the vertex and comparing the size of responses in the first dorsal interosseous (FDI) muscles evoked by anticlockwise and clockwise [corrected] coil currents. In normal subjects, right FDI responses are larger with anticlockwise currents than with clockwise [corrected] currents at the same stimulation strength and vice versa. In two out of three patients with congenital mirror movements, this sensitivity of response amplitude to coil current direction was reversed. The third patient with congenital mirror movements and a fourth patient with acquired mirror movements had responses which were normally sensitive to current direction. These findings support the hypothesis that some cases of congenital mirror movements may be due to abnormal projection of corticomotoneuronal pathways.
利用磁运动皮层刺激对3例先天性镜像运动患者的中枢运动通路进行了研究。反应阈值、波幅和潜伏期均正常。通过将线圈置于头顶并比较逆时针和顺时针[校正后]线圈电流诱发的第一背侧骨间肌（FDI）肌肉反应的大小，评估皮质运动神经元通路的投射。在正常受试者中，在相同刺激强度下，逆时针电流诱发的右侧FDI反应大于顺时针[校正后]电流诱发的反应，反之亦然。在3例先天性镜像运动患者中的2例，反应波幅对线圈电流方向的这种敏感性发生了逆转。第3例先天性镜像运动患者和第4例后天性镜像运动患者的反应对电流方向的敏感性正常。这些发现支持了以下假说，即某些先天性镜像运动病例可能是由于皮质运动神经元通路投射异常所致。
