Sharief M K, Hentges R, Thomas E
Department of Clinical Neurochemistry, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
Neurology. 1991 Sep;41(9):1398-401. doi: 10.1212/wnl.41.9.1398.
We examined the intrathecal production of immunoglobulins (Ig) G, A, and M in 16 patients with Behçet's disease, 13 of whom have CNS involvement, and in 40 neurologic controls. Oligoclonal IgA and IgM bands were mainly detected in CSF samples from patients with active neuro-Behçet's disease and were documented to disappear when neurologic manifestations remit. Oligoclonal IgG bands, however, were not related to disease activity and were also found in some neurologic controls. High immunoglobulin index values were detected in both active and quiescent diseases and were high in some patients with impaired blood-CSF barriers. The study presented here demonstrates that CSF oligoclonal IgA and IgM may be helpful in monitoring CNS disease activity in neuro-Behçet's and could be useful in understanding the pathogenesis of this disease.
我们检测了16例白塞病患者鞘内免疫球蛋白（Ig）G、A和M的产生情况，其中13例有中枢神经系统受累，同时检测了40例神经科对照者。寡克隆IgA和IgM条带主要在活动性神经白塞病患者的脑脊液样本中检测到，并且在神经症状缓解时消失。然而，寡克隆IgG条带与疾病活动无关，在一些神经科对照者中也有发现。在疾病活动期和静止期均检测到高免疫球蛋白指数值，一些血脑屏障受损的患者该值也较高。本研究表明，脑脊液寡克隆IgA和IgM可能有助于监测神经白塞病中枢神经系统疾病的活动情况，并有助于理解该疾病的发病机制。
