Chen Shang-jie, Liu Bo, Fu Wen-bin, Wu Shan-shan, Chen Jun, Ran Peng-cheng
Department of Rehabilitation, Baoan People's Hospital, Shenzhen 518101, China.
Zhen Ci Yan Jiu. 2008 Aug;33(4):267-71.
To observe the influence of acupuncture of Shenmen (HT 7) and Yanglao (SI 6) on neuro-images in different cerebral regions in volunteer subjects.
Twelve healthy young volunteer participants were enrolled in this research. fMRI scans were taken in random order in a block design (one for baseline and two for acupuncture stimulations). During stimulation phase, an acupuncture needle inserted in right HT7 or S16 was twirled at an angle of 180 degrees and a frequency of about 1.5 Hz for 35. 6 ms. Main parameters for fMRI were TR/TE/FA = 3560 ms/50 ms/90 degrees. Acupuncture sensations were evaluated by means of visual analog scale (VAS). The collected images were analyzed by using SPM 2 for exploring inter-group differences in blood oxygen level dependent (BOLD) responses.
When manipulating the needle, both the operator and the subject had a feeling of Deqi. Increases in BOLD signal (group analysis, corrected, 0.05, K > or =10) were found mainly in right postcentral gyrus of frontal lobe (BA 2, BA 1, BA 43), left inferior frontal gyrus (BA 47), secondarily, in the right inferior parietal lobule (BA 40), right inferior frontal gyrus (BA 44), left superior temporal gyrus (BA 22) and right insula (BA 40) after acupuncture at HT7; and chiefly in left inferior parietal lobule (BA 40), right inferior frontal gyrus (BA 45, BA 46), secondarily in the left middle temporal gyrus and inferior temporal gyrus (BA 37) as well as the left superior frontal gyrus (BA 10) after acupuncture of S16.
Acupuncture of HT7 and SI6 elicite different BOLD responses in some related cerebral regions.
观察针刺神门穴（HT 7）和养老穴（SI 6）对志愿者不同脑区神经影像的影响。
本研究纳入12名健康青年志愿者。采用组块设计以随机顺序进行功能磁共振成像（fMRI）扫描（一次基线扫描和两次针刺刺激扫描）。在刺激阶段，将一根针刺入右侧HT7或SI6，以180度角、约1.5赫兹的频率捻转35.6毫秒。fMRI的主要参数为TR/TE/FA = 3560毫秒/50毫秒/90度。采用视觉模拟量表（VAS）评估针刺感觉。使用SPM 2分析采集的图像，以探索组间血氧水平依赖（BOLD）反应的差异。
针刺时，术者和受试者均有得气感。针刺HT7后，BOLD信号增强（组分析，校正后，P<0.05，K≥10）主要见于右侧额叶中央后回（BA 2、BA 1、BA 43）、左侧额下回（BA 47），其次见于右侧顶下小叶（BA 40）、右侧额下回（BA 44）、左侧颞上回（BA 22）和右侧脑岛（BA 40）；针刺SI6后，主要见于左侧顶下小叶（BA 40）、右侧额下回（BA 45、BA 46），其次见于左侧颞中回和颞下回（BA 37）以及左侧额上回（BA 10）。
针刺HT7和SI6在一些相关脑区引发不同的BOLD反应。
