细胞凋亡：BAX蛋白遭“刺中”。
Apoptosis: Stabbed in the BAX.
作者信息
Green Douglas R, Chipuk Jerry E
出版信息
Nature. 2008 Oct 23;455(7216):1047-9. doi: 10.1038/4551047a.
Abstract
Apoptotic cell death is an intricate and highly regulated process. To initiate apoptosis, the protein BIM binds to a hitherto unrecognized site on the BAX protein to trigger permeabilization of the outer mitochondrial membrane.
摘要
凋亡性细胞死亡是一个复杂且受到高度调控的过程。为启动凋亡，蛋白质BIM会与BAX蛋白上一个此前未被识别的位点结合，从而引发线粒体外膜的通透性改变。
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To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.为了触发细胞凋亡，Bak会暴露其BH3结构域，并通过BH3：凹槽相互作用形成同型二聚体。
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