Kimura N T, Kanematsu T, Baba T
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976 Dec 9;87(3):257-66. doi: 10.1007/BF00506498.
The effects of dietary polychlorinated biphenyls (PCBs) on hepatocarcinogenesis in female rats of Donryu strain receiving 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB) were investigated. Oral administration of PCBs after administration of 3'-Me-DAB resulted in a high incidence (64%) of hepatocarcinoma. In contrast, administration of a similar amount of PCBs before, or together with 3'-Me-DAB did not induce hepatic tumors. Administration of a slightly larger amount of PCBs alone did not induce liver tumors, while administration of a slightly larger amount of 3'-Me-DAB alone caused only a low incidence (13%) of hepatocarcinoma. These results strongly suggest that PCBs exert a potent promoting action in experimental azo dye hepatocarcinogenesis.
研究了膳食多氯联苯（PCBs）对接受3'-甲基-4-二甲基氨基偶氮苯（3'-Me-DAB）的唐育品系雌性大鼠肝癌发生的影响。在给予3'-Me-DAB后口服PCBs导致肝癌的高发生率（64%）。相比之下，在给予3'-Me-DAB之前或同时给予等量的PCBs不会诱发肝脏肿瘤。单独给予稍大量的PCBs不会诱发肝脏肿瘤，而单独给予稍大量的3'-Me-DAB仅导致肝癌的低发生率（13%）。这些结果有力地表明，PCBs在实验性偶氮染料肝癌发生中发挥强大的促进作用。
