Lanhers M C, Fleurentin J, Dorfman P, Mortier F, Pelt J M
Laboratoire de Pharmacognosie, Université de Metz, France.
Planta Med. 1991 Jun;57(3):225-31. doi: 10.1055/s-2006-960079.
Lyophilised aqueous extract of Euphorbia hirta L. (Euphorbiaceae) has been evaluated for analgesic, antipyretic and anti-inflammatory properties in mice and rats, in order to complete its activity profile, after the confirmation of the existence of a central depressant activity particularly expressed by a strong sedative effect, associated with anxiolytic effects. This study leads us to the conclusion that this plant extract exerts central analgesic properties. Such a dose-dependent action was obtained against chemical (writhing test) and thermic (hot plate test) stimuli, respectively, from the doses of 20 and 25 mg/kg and it was inhibited by a naloxone pretreatment, a specific morphinic antagonist compound. An antipyretic activity was obtained at the sedative doses of 100 and 400 mg/kg, on the yeast-induced hyperthermia. Finally, significant and dose-dependent anti-inflammatory effects were observed on an acute inflammatory process (carrageenan-induced edema test in rats) from the dose of 100 mg/kg. On the other hand, plant extract remained inactive on chronic processes such as Freund's adjuvant-induced rheumatoid arthritis, after a chronic treatment during fourteen days at the daily dose of 200 or 400 mg/kg; however, if inefficacy was observed on rat backpaws edema and on loss of weight, the aqueous extract reduced the inflammatory hyperalgia.
对大戟科大戟的冻干水提取物在小鼠和大鼠中进行了镇痛、解热和抗炎特性评估，以完善其活性谱。此前已证实其存在中枢抑制活性，尤其表现为强烈的镇静作用，并伴有抗焦虑作用。本研究使我们得出结论，该植物提取物具有中枢镇痛特性。分别从20和25毫克/千克的剂量开始，对化学刺激（扭体试验）和热刺激（热板试验）产生了这种剂量依赖性作用，且该作用被纳洛酮预处理（一种特异性吗啡拮抗剂化合物）所抑制。在100和400毫克/千克的镇静剂量下，对酵母诱导的高热有解热活性。最后，在大鼠角叉菜胶诱导的水肿试验的急性炎症过程中，从100毫克/千克的剂量开始观察到显著且剂量依赖性的抗炎作用。另一方面，在以200或400毫克/千克的日剂量进行14天的慢性治疗后，植物提取物对弗氏佐剂诱导的类风湿性关节炎等慢性过程无活性；然而，尽管在大鼠后爪水肿和体重减轻方面观察到无效，但水提取物减轻了炎症性痛觉过敏。
