Miège Cécile, Favier Maxime, Brosse Corinne, Canler Jean-Pierre, Coquery Marina
Cemagref, Water Quality and Pollution Control Research Unit, 3 bis quai Chauveau, CP 220, F-69336 Lyon, France.
Talanta. 2006 Nov 15;70(4):739-44. doi: 10.1016/j.talanta.2006.07.002. Epub 2006 Aug 17.
Five betablockers (oxprenolol, metoprolol, propranolol, bisoprolol, betaxolol) were analysed in effluents collected over a 3-month period from wastewater treatment plants (WTP) from the Lyon area in France. The analytical protocol consisted of solid phase extraction of the dissolved aqueous phase on HLB cartridges and analysis by gas chromatography coupled with mass detection (GC-MS) after derivatization. Concentrations of metoprolol, propranolol and bisoprolol varied from 45 to 2838ng/L whereas oxprenolol and betaxolol were never detected in these effluent samples. A high variability of betablockers concentrations and fluxes was observed between WTP effluents and within each WTP over the time period studied. Considering a flux per person for a dry weather period, Fontaine plant was pointed out as the less efficient WTP, which might be explained by its type of treatment (biological aerated filters). But we need additional analysis of effluent and influent waters to confirm this hypothesis. A tentative approach of local environmental risk assessment of propranolol based on the calculation of PEC/PNEC (predicted environmental concentration/predicted non effect concentration) ratio approach lead us to conclude on a negligible risk for the downstream rivers (Rhône river at Ternay and Saône river at Couzon Mt d'Or).
对法国里昂地区污水处理厂（WTP）在3个月期间收集的废水中的5种β受体阻滞剂（氧烯洛尔、美托洛尔、普萘洛尔、比索洛尔、倍他洛尔）进行了分析。分析方案包括在HLB柱上对溶解的水相进行固相萃取，并在衍生化后通过气相色谱-质谱检测（GC-MS）进行分析。美托洛尔、普萘洛尔和比索洛尔的浓度在45至2838纳克/升之间变化，而在这些废水样品中从未检测到氧烯洛尔和倍他洛尔。在所研究的时间段内，污水处理厂出水之间以及每个污水处理厂内部均观察到β受体阻滞剂浓度和通量的高度变异性。考虑到旱季每人的通量，方丹工厂被指出是效率最低的污水处理厂，这可能是由其处理类型（生物曝气滤池）所解释的。但我们需要对出水和进水进行额外分析以证实这一假设。基于预测环境浓度/预测无效应浓度（PEC/PNEC）比值法对方丹洛尔进行的局部环境风险评估的初步方法使我们得出结论，下游河流（特奈的罗纳河和库宗山多尔的索恩河）的风险可忽略不计。
