Coutinho Henrique Douglas M, Falcão-Silva Vivyanne S, Gonçalves Gregório Fernandes
Laboratório de Pesquisa em Produtos Naturais, Departamento de Ciências físicas e Biológicas, Centro de Ciências Biológicas e da Saúde, Universidade Regional do Cariri, Crato (CE), Brazil.
Int Arch Med. 2008 Nov 7;1(1):24. doi: 10.1186/1755-7682-1-24.
Cystic fibrosis is the most common and best known genetic disease involving a defect in transepithelial Cl- transport by mutations in the CF gene on chromosome 7, which codes for the cystic fibrosis transmembrane conductance regulator protein (CFTR). The most serious symptoms are observed in the lungs, augmenting the risk of bacterial infection. The objective of this review was to describe the bacterial pathogens colonizing patients with cystic fibrosis. A systematic search was conducted using the international bibliographic databanks SCIELO, HIGHWIRE, PUBMED, SCIRUS and LILACS to provide a useful and practical review for healthcare workers to make them aware of these microorganisms. Today, B. cepacia, P. aeruginosa and S. aureus are the most important infectious agents in cystic fibrosis patients. However, healthcare professionals must pay attention to emerging infectious agents in these patients, because they represent a potentially serious future problem. Therefore, these pathogens should be pointed out as a risk to these patients, and hospitals all over the world must be prepared to detect and combat these bacteria.
囊性纤维化是最常见且最为人熟知的遗传性疾病，它涉及7号染色体上CF基因的突变导致跨上皮氯离子转运缺陷，该基因编码囊性纤维化跨膜传导调节蛋白（CFTR）。最严重的症状出现在肺部，增加了细菌感染的风险。本综述的目的是描述定植于囊性纤维化患者体内的细菌病原体。通过使用国际文献数据库SCIELO、HIGHWIRE、PUBMED、SCIRUS和LILACS进行系统检索，为医护人员提供一份有用且实用的综述，使他们了解这些微生物。如今，洋葱伯克霍尔德菌、铜绿假单胞菌和金黄色葡萄球菌是囊性纤维化患者中最重要的感染病原体。然而，医护专业人员必须关注这些患者中出现的感染病原体，因为它们代表着未来一个潜在的严重问题。因此，应指出这些病原体对这些患者构成的风险，全世界的医院都必须做好检测和对抗这些细菌的准备。
