Leite Mylene, Ponte Eduardo Vieira, Petroni Jaqueline, D'Oliveira Júnior Argemiro, Pizzichini Emílio, Cruz Alvaro Augusto
Programa de Controle da Asma e Rinite Alérgica na Bahia, Salvador, BA, Brasil.
J Bras Pneumol. 2008 Oct;34(10):756-63. doi: 10.1590/s1806-37132008001000002.
To evaluate whether the Portuguese version of the Asthma Control Questionnaire (ACQ) is a valid instrument to measure asthma control in adult outpatients in Brazil.
We selected 278 outpatients diagnosed with asthma. All of the patients completed the questionnaire, underwent spirometry and were clinically evaluated by a physician in order to characterize the control of the disease in the first visit. The questionnaire was evaluated in three versions, with 5, 6 and 7 questions, respectively, and scores of 0.75 and 1.50 were used as cut-off points.
Of the 278 patients, 77 (27.7%) had intermittent asthma, 39 (14.0%) had mild persistent asthma, 40 (14.4%) had moderate persistent asthma and 122 (43.9%) had severe persistent asthma. The sensitivity of ACQ to identify uncontrolled asthma ranged from 77% to 99%, and the specificity ranged from 36% to 84%. The positive predictive value ranged from 73% to 90%, and the negative predictive value ranged from 67% to 95%. The positive likelihood ratio ranged from 1.55 to 4.81, and the negative likelihood ratio ranged from 0.03 to 0.27. In the 5- and 6-question versions of the ACQ, the intraclass correlation coefficient was 0.92. These two versions were both responsive to clinical changes in the patients.
All three versions of the ACQ satisfactorily discriminated between patients with uncontrolled asthma and those with controlled asthma. The 5- and 6-question versions also presented good reliability and responsiveness. Therefore, the ACQ is a valid tool for evaluating asthma control in adult outpatients in Brazil.
评估葡萄牙语版哮喘控制问卷（ACQ）是否为衡量巴西成年门诊患者哮喘控制情况的有效工具。
我们选取了278名被诊断为哮喘的门诊患者。所有患者均完成问卷，进行肺功能测定，并由医生进行临床评估，以在首次就诊时对疾病控制情况进行特征描述。问卷以三个版本进行评估，分别有5、6和7个问题，且分别以0.75和1.50的分数作为分界点。
278名患者中，77名（27.7%）患有间歇性哮喘，39名（14.0%）患有轻度持续性哮喘，40名（14.4%）患有中度持续性哮喘，122名（43.9%）患有重度持续性哮喘。ACQ识别未控制哮喘的敏感性范围为77%至99%，特异性范围为36%至84%。阳性预测值范围为73%至90%，阴性预测值范围为67%至95%。阳性似然比范围为1.55至4.81，阴性似然比范围为0.03至0.27。在ACQ的5题和6题版本中，组内相关系数为0.92。这两个版本均对患者的临床变化有反应。
ACQ的所有三个版本都能令人满意地区分未控制哮喘患者和已控制哮喘患者。5题和6题版本还具有良好的可靠性和反应性。因此，ACQ是评估巴西成年门诊患者哮喘控制情况的有效工具。
