Koskinen Tuomas, Kähönen Mika, Jula Antti, Laitinen Tomi, Keltikangas-Järvinen Liisa, Viikari Jorma, Välimäki Ilkka, Raitakari Olli T
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland.
Auton Neurosci. 2009 Jan 28;145(1-2):81-8. doi: 10.1016/j.autneu.2008.10.011. Epub 2008 Nov 18.
Reduced short-term heart rate variability (HRV) is a risk factor for cardiovascular morbidity and total mortality. The reference values of short-term HRV indices in healthy young adults are unknown. To investigate age and sex differences in HRV and to generate reference values of short-term recordings, we examined 1780 healthy subjects aged 24 to 39 years. Both frequency and time domain HRV indices were computed. Indices included; low frequency (LF), high frequency (HF) and total components of spectral-HRV, the square root of mean squared differences of R-R-intervals and SD of normal R-R-intervals. Deep breathing test was performed and the mean ratio of R-R-intervals and the mean difference in instantaneous heart rate during breathing cycle were analyzed. Reproducibility of these indices was studied in 43 subjects. Aging and higher heart rate were inversely associated with all HRV indices (all p values <0.0001). Women had higher HF and lower LF compared to men (both p<0.0001). Women had higher resting heart rate (70 vs. 65 bpm, p<0.0001). The reproducibility of HRV indices and deep breathing test were good (CV 5.3-13.9%). We conclude that age, sex and heart rate needs to be considered when evaluating HRV indices and when generating reference values. Because of good reproducibility the short-term indices of HRV and deep breathing test can be used in clinical work.
短期心率变异性（HRV）降低是心血管疾病发病率和总死亡率的一个风险因素。健康年轻成年人短期HRV指标的参考值尚不清楚。为了研究HRV的年龄和性别差异并生成短期记录的参考值，我们对1780名年龄在24至39岁的健康受试者进行了检查。计算了频域和时域HRV指标。指标包括：低频（LF）、高频（HF）和频谱HRV的总成分、R-R间期均方根差值以及正常R-R间期标准差。进行了深呼吸测试，并分析了R-R间期的平均比值和呼吸周期中瞬时心率的平均差值。在43名受试者中研究了这些指标的可重复性。年龄增长和心率加快与所有HRV指标均呈负相关（所有p值<0.0001）。与男性相比，女性的HF较高，LF较低（均p<0.0001）。女性静息心率较高（70对65次/分钟，p<0.0001）。HRV指标和深呼吸测试的可重复性良好（变异系数5.3-13.9%）。我们得出结论，在评估HRV指标和生成参考值时，需要考虑年龄、性别和心率。由于可重复性良好，HRV的短期指标和深呼吸测试可用于临床工作。
