Cerdas-Quesada César-Alonso, Retana-Salazar Axel P
Caja Costarricense del Seguro Social, Hospital San Juan de Dios, Departamento de Análisis Clinico y Microbiología, San José, Costa Rica.
Rev Biol Trop. 2007 Jun;55(2):365-72. doi: 10.15517/rbt.v55i2.6016.
Phylogenetic analysis of the envelope gene sequence (E) of three isolated Dengue virus type 1 (DEN-1) sequences from the Costa Rican 1993 epidemic was performed. All the strains fell into genotype V. Genotype V has grouped all the strains isolated from America, three strains from Africa and two strains from Asia. Costa Rican strains are closely related to the strain from Angola and to the Brazil 1990 strain. Costa Rican strains are able to cause DHF but with low clinical disease severity and low incidence maybe because of low virulence.
对来自哥斯达黎加1993年疫情的三株分离登革病毒1型（DEN-1）包膜基因序列（E）进行了系统发育分析。所有菌株均属于基因型V。基因型V将从美洲分离的所有菌株、来自非洲的三株菌株和来自亚洲的两株菌株归为一组。哥斯达黎加菌株与来自安哥拉的菌株以及巴西1990年的菌株密切相关。哥斯达黎加菌株能够引起登革出血热，但临床疾病严重程度较低且发病率较低，可能是因为毒力较低。
