用于11个X染色体短串联重复序列（STR）标记的多重聚合酶链反应（PCR）以及来自巴西亚马逊地区的群体数据。
A multiplex PCR for 11 X chromosome STR markers and population data from a Brazilian Amazon Region.
作者信息
Ribeiro Rodrigues Elzemar Martins, Leite Fabio Pereira das Neves, Hutz Mara Helena, Palha Teresinha de Jesus Brabo Ferreira, Ribeiro dos Santos Andrea Kely Campos, dos Santos Sidney Emanuel Batista
机构信息
Laboratório de Genética Humana e Médica, Departamento de Patologia, Universidade Federal do Pará, Belém, Pará, Brazil.
出版信息
Forensic Sci Int Genet. 2008 Mar;2(2):154-8. doi: 10.1016/j.fsigen.2007.10.179. Epub 2007 Dec 4.
The analysis of X-STR polymorphisms has received the attention of several researchers, mainly due to its applicability to the investigation of complex kinship cases. Although many X-STRs have been validated for forensic use, little is known about the variations of these polymorphisms in different populations of the world. The present work describes a new multiplex system that allows the simultaneous analysis of 11 X-STR markers, for use both in paternity determination and more complex forensic cases. The loci investigated include DXS9895, DXS7132, DXS6800, DXS9898, DXS6789, DXS7133, DXS7130, HPRTB, GATA31E08, DXS7423, and DXS10011, which together afford a power of discrimination in the order of 0.999999. In addition, this work presents the genotyping results obtained for a sample of 324 individuals (182 males and 142 females) from the admixed population of Belém, Pará, located in the Brazilian Amazon Region.
X染色体短串联重复序列（X-STR）多态性分析已引起了多位研究人员的关注，主要是因为它适用于复杂亲属关系案件的调查。尽管许多X-STR已被验证可用于法医鉴定，但对于这些多态性在世界不同人群中的变异情况却知之甚少。本研究描述了一种新的复合扩增系统，该系统可同时分析11个X-STR标记，用于亲子鉴定和更复杂的法医案件。所研究的基因座包括DXS9895、DXS7132、DXS6800、DXS9898、DXS6789、DXS7133、DXS7130、HPRTB、GATA31E08、DXS7423和DXS10011，它们共同提供了约0.999999的鉴别力。此外，本研究还展示了从位于巴西亚马逊地区帕拉州贝伦市的混合人群中选取的324名个体（182名男性和142名女性）样本的基因分型结果。
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