Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of CAS, Chinese Academy of Sciences, 319 Yue Yang Road, Shanghai 200031, China.
PPAR Res. 2008;2008:581348. doi: 10.1155/2008/581348. Epub 2008 Dec 11.
Peroxisome proliferator-activated receptors (PPARs) are transcriptional factors involved in the regulation of insulin resistance and adipogenesis. Cinnamon, a widely used spice in food preparation and traditional antidiabetic remedy, is found to activate PPARgamma and alpha, resulting in improved insulin resistance, reduced fasted glucose, FFA, LDL-c, and AST levels in high-caloric diet-induced obesity (DIO) and db/db mice in its water extract form. In vitro studies demonstrate that cinnamon increases the expression of peroxisome proliferator-activated receptors gamma and alpha (PPARgamma/alpha) and their target genes such as LPL, CD36, GLUT4, and ACO in 3T3-L1 adipocyte. The transactivities of both full length and ligand-binding domain (LBD) of PPARgamma and PPARalpha are activated by cinnamon as evidenced by reporter gene assays. These data suggest that cinnamon in its water extract form can act as a dual activator of PPARgamma and alpha, and may be an alternative to PPARgamma activator in managing obesity-related diabetes and hyperlipidemia.
过氧化物酶体增殖物激活受体 (PPARs) 是参与调节胰岛素抵抗和脂肪生成的转录因子。肉桂，一种在食品制备和传统抗糖尿病疗法中广泛使用的香料，被发现能激活 PPARγ 和α，从而改善胰岛素抵抗，降低高热量饮食诱导肥胖 (DIO) 和 db/db 小鼠的空腹血糖、FFA、LDL-c 和 AST 水平。体外研究表明，肉桂能增加 3T3-L1 脂肪细胞中过氧化物酶体增殖物激活受体 γ 和 α (PPARγ/α) 及其靶基因如 LPL、CD36、GLUT4 和 ACO 的表达。肉桂能激活全长和配体结合域 (LBD) 的 PPARγ 和 PPARα 的转录活性，这一点通过报告基因检测得到了证实。这些数据表明，肉桂的水提取物可以作为 PPARγ 和α 的双重激活剂，可能是管理肥胖相关糖尿病和高血脂症的 PPARγ 激活剂的替代品。
