Uddman R, Luts A, Arimura A, Sundler F
Department of Otorhinolaryngology, Malmö General Hospital, Sweden.
Cell Tissue Res. 1991 Jul;265(1):197-201. doi: 10.1007/BF00318155.
Pituitary adenylate cyclase-activating peptide (PACAP) is a vasoactive intestinal peptide (VIP)-like peptide recently isolated from ovine hypothalami. Nerve fibers displaying PACAP immunoreactivity were found in the respiratory tract of rats, guinea pigs, ferrets, pigs, sheep and squirrel monkeys. A moderate supply of PACAP-immunoreactive fibers was seen in the nasal mucosa of guinea pigs. Few to moderate numbers of PACAP-containing fibers occurred in the tracheo-bronchial wall of rats, guinea pigs, ferrets, pigs, sheep and squirrel monkeys. The fibers were distributed beneath the epithelium, around blood vessels and seromucous glands, and among bundles of smooth muscle. In the lungs, the immunoreactive fibers were observed close to small bronchioli. A few PACAP-immunoreactive nerve cell bodies were seen in the sphenopalatine and otic ganglia of guinea pigs. Simultaneous double immunostaining of the respiratory tract of sheep and ferrets revealed that all PACAP-containing nerve fibers stored VIP. We suggest that neuronal PACAP may take part in the regulation of smooth muscle tone and glandular secretion.
垂体腺苷酸环化酶激活肽（PACAP）是一种最近从绵羊下丘脑分离出来的类似血管活性肠肽（VIP）的肽。在大鼠、豚鼠、雪貂、猪、绵羊和松鼠猴的呼吸道中发现了显示PACAP免疫反应性的神经纤维。在豚鼠的鼻粘膜中可见适量的PACAP免疫反应性纤维。在大鼠、豚鼠、雪貂、猪、绵羊和松鼠猴的气管支气管壁中，含有PACAP的纤维数量少至中等。这些纤维分布在上皮下方、血管和浆液粘液腺周围以及平滑肌束之间。在肺中，免疫反应性纤维靠近小支气管。在豚鼠的蝶腭神经节和耳神经节中可见一些PACAP免疫反应性神经细胞体。对绵羊和雪貂呼吸道的同时双重免疫染色显示，所有含有PACAP的神经纤维都储存有VIP。我们认为神经元PACAP可能参与平滑肌张力和腺体分泌的调节。
