荧光光学投影断层成像的归一化玻恩比率
Normalized Born ratio for fluorescence optical projection tomography.
作者信息
Vinegoni Claudio, Razansky Daniel, Figueiredo Jose-Luiz, Nahrendorf Matthias, Ntziachristos Vasilis, Weissleder Ralph
机构信息
Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
出版信息
Opt Lett. 2009 Feb 1;34(3):319-21. doi: 10.1364/ol.34.000319.
Abstract
We present a normalized Born approach for fluorescence optical projection tomography that takes into account tissue absorption properties. This approach can be particularly useful to study fluorochrome distribution within tissue. We use the algorithm to three-dimensionally reconstruct and characterize a fluorescein isothiocyanate containing absorptive phantom and an infarcted mouse heart previously injected with a fluorescent molecular probe.
摘要
我们提出了一种用于荧光光学投影断层扫描的归一化玻恩方法，该方法考虑了组织吸收特性。这种方法对于研究荧光染料在组织内的分布可能特别有用。我们使用该算法对含有异硫氰酸荧光素的吸收性模型以及先前注射了荧光分子探针的梗死小鼠心脏进行三维重建和表征。
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