Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
Tissue Eng Part B Rev. 2009 Jun;15(2):143-57. doi: 10.1089/ten.TEB.2008.0563.
Articular cartilage damage is a persistent and increasing problem with the aging population, and treatments to achieve biological repair or restoration remain a challenge. Cartilage tissue engineering approaches have been investigated for over 20 years, but have yet to achieve the consistency and effectiveness for widespread clinical use. One of the potential reasons for this is that the engineered tissues do not have or establish the normal zonal organization of cells and extracellular matrix that appears critical for normal tissue function. A number of approaches are being taken currently to engineer tissue that more closely mimics the organization of native articular cartilage. This review focuses on the zonal organization of native articular cartilage, strategies being used to develop such organization, the reorganization that occurs after culture or implantation, and future prospects for the tissue engineering of articular cartilage with biomimetic zones.
关节软骨损伤是老龄化人口中持续存在且日益严重的问题，而实现生物修复或再生的治疗仍然是一个挑战。关节软骨组织工程方法已经研究了 20 多年，但尚未达到广泛临床应用的一致性和有效性。造成这种情况的一个潜在原因是，工程化组织没有或无法建立细胞和细胞外基质的正常分区组织，而这种分区组织对于正常组织功能至关重要。目前正在采取许多方法来构建更接近天然关节软骨组织的分区组织。本综述重点介绍了天然关节软骨的分区组织、开发这种组织的策略、培养或植入后发生的重组以及具有仿生分区的关节软骨组织工程的未来前景。
