Svircev Zorica, Krstic Svetislav, Miladinov-Mikov Marica, Baltic Vladimir, Vidovic Milka
Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Serbia.
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009 Jan;27(1):36-55. doi: 10.1080/10590500802668016.
A large part of Central Serbia experiences continual shortage of sufficient ground water resources. For that reason, more than 20 reservoirs serve as drinking water suppliers. Significant and persistent cyanobacterial "blooms" have been recognized in nine of them. Samples for cyanotoxin analyses were taken during and after "blooms" in Celije Reservoir and from Krusevac town-supplied tap water from that reservoir two days later. Concentration of microcystin-LR was 650 microg L(-1) in the reservoir, while the tap water contained 2.5 microg L(-1). In the two investigated periods, the high primary liver cancer (PLC) mortality of 11.6 from 1980-1990 and extremely high PLC incidence of 34.7 from 2000-2002 were observed in the regions affected by heavy cyanobacterial "blooms." In contrast, PLC mortality and incidence rates were substantially lower in the regions not affected by cyanobacterial blooms: in 1980-1990 the rate of PLC mortality amounted to 2.7 in Kosovo, 7.6 in Vojvodina, and 8.3 in the non-affected regions of Central Serbia; while in 2000-2002 PLC incidence amounted to 4.1 in Kosovo, 5.2 in Vojvodina, and 13.6 in the non- or less-affected regions of Central Serbia. Keeping in mind that the most affected PLC regions in Central Serbia (Toplicki, Niski, and Sumadijski regions) have the water supply systems based on six reservoirs found regularly in bloom during summer months and that some of the regions are also connected with two boundary "blooming" reservoirs, representing a total of eight of nine blooming reservoirs, it is easy to presume that the PLC incidence could be related to drinking water quality. The uneven geographic distribution of liver cancer in Serbia is conspicuous and hot spots could be related to drinking water supply. It is very clear that the high-risk regions for PLC occurrence correspond with drinking water reservoirs continually found with cyanobacterial blooms, and the low risk regions correspond with water supplies not affected by cyanobacteria.
塞尔维亚中部的大部分地区长期面临充足地下水资源短缺的问题。因此，20多个水库充当饮用水供应源。其中9个水库已出现显著且持续的蓝藻“水华”现象。在塞利耶水库“水华”期间及之后采集了蓝藻毒素分析样本，并在两天后从克鲁舍瓦茨镇取自该水库的自来水进行采样。水库中微囊藻毒素-LR的浓度为650微克/升，而自来水中含有2.5微克/升。在两个调查时期，受严重蓝藻“水华”影响的地区观察到1980 - 1990年原发性肝癌（PLC）高死亡率为11.6，以及2000 - 2002年极高的PLC发病率为34.7。相比之下，未受蓝藻水华影响的地区PLC死亡率和发病率则低得多：1980 - 1990年，科索沃的PLC死亡率为2.7，伏伊伏丁那为7.6，塞尔维亚中部未受影响地区为8.3；而在2000 - 2002年，科索沃的PLC发病率为4.1，伏伊伏丁那为5.2，塞尔维亚中部未受或受影响较小地区为13.6。考虑到塞尔维亚中部受PLC影响最严重的地区（托普利察、尼斯基和舒马迪亚地区）的供水系统基于夏季经常出现水华的6个水库，并且其中一些地区还与两个边界“水华”水库相连，这9个水华水库中共有8个，很容易推测PLC发病率可能与饮用水质量有关。塞尔维亚肝癌的地理分布不均衡很明显，热点地区可能与饮用水供应有关。很明显，PLC发生的高风险地区与持续出现蓝藻水华的饮用水水库相对应，而低风险地区与未受蓝藻影响的供水相对应。
