单核铜(II)-过氧配合物模拟了 PHM 和 DbetaM 的活性中心的结构和反应性。
Mononuclear copper(II)-superoxo complexes that mimic the structure and reactivity of the active centers of PHM and DbetaM.
机构信息
Department of Chemistry, Graduate School of Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan.
出版信息
J Am Chem Soc. 2009 Mar 4;131(8):2788-9. doi: 10.1021/ja809464e.
Mononuclear copper(II)-superoxo complexes 2(X)-OO() having triplet (S = 1) ground states were obtained via reaction of O(2) with the copper(I) starting materials 1(X) supported by tridentate ligands L(X) [1-(2-p-X-phenethyl)-5-(2-pyridin-2-ylethyl)-1,5-diazacyclooctane; X = CH(3), H, NO(2)] in various solvents. The superoxo complexes 2(X)-OO() mimic the structure [tetrahedral geometry with an end-on (eta(1))-bound O(2)(*-)] and the aliphatic C-H bond activation chemistry of peptidylglycine alpha-hydroxylating monooxygenase and dopamine beta-monooxygenase.
单核铜（II）-过氧配合物 2(X)-OO() 具有三重态（S = 1）基态，通过 O(2)与铜（I）起始材料 1(X) 在各种溶剂中反应获得，该起始材料由三齿配体 L(X) [1-(2-p-X-苯乙基）-5-(2-吡啶-2-乙基）-1,5-二氮杂环辛烷；X = CH(3), H, NO(2)] 支持。过氧配合物 2(X)-OO() 模拟了结构 [具有端接（eta(1))-结合的 O(2)(*-)] 的四面体几何形状和肽基甘氨酸 α-羟化单加氧酶和多巴胺 β-单加氧酶的脂肪族 C-H 键活化化学。
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