自私的DNA：归巢内切酶找到了归宿。
Selfish DNA: homing endonucleases find a home.
作者信息
Edgell David R
机构信息
Department of Biochemistry, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, Canada.
出版信息
Curr Biol. 2009 Feb 10;19(3):R115-7. doi: 10.1016/j.cub.2008.12.019.
Self-splicing group I introns come in two flavours - those with a homing endonuclease to promote mobility of the intron, and those without an endonuclease. How homing endonucleases and self-splicing introns associate to form a composite selfish genetic element is a question of long-standing interest. Recent work has revealed that a shared characteristic of both introns and endonucleases, the targeting of conserved sequences, may provide the impetus for the evolution of composite mobile genetic elements.
自我剪接的I类内含子有两种类型——一种带有归巢内切酶以促进内含子的移动，另一种则没有内切酶。归巢内切酶和自我剪接内含子如何相互作用形成一个复合的自私遗传元件，这是一个长期以来备受关注的问题。最近的研究表明，内含子和内切酶的一个共同特征，即对保守序列的靶向作用，可能为复合移动遗传元件的进化提供了动力。
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