Zhang X, Xie P, Li D, Tang R, Lei H, Zhao Y
Fisheries College of Huazhong Agricultural University, 430070, Wuhan, People's Republic of China.
Bull Environ Contam Toxicol. 2009 May;82(5):574-8. doi: 10.1007/s00128-009-9671-2. Epub 2009 Feb 28.
This study was conducted to investigate time-dependent changes in oxidative enzymes in liver of crucian carp after intraperitoneally injection with extracted microcystins 600 and 150 microg kg(-1) body weight. The results showed that activities of antioxidant enzymes, including superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase generally exhibited a rapid increase in early phase (1-3 h post injection), but gradually decreased afterwards (12-48 h) compared with the control, with an evident time-dependent effect. These zigzag changes over time contributed a better understanding on oxidative stress caused by microcystins in fish.
本研究旨在探讨腹腔注射600和150微克/千克体重的提取微囊藻毒素后，鲫鱼肝脏中氧化酶随时间的变化。结果表明，抗氧化酶（包括超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶和谷胱甘肽还原酶）的活性在早期阶段（注射后1-3小时）通常迅速增加，但与对照组相比，随后（12-48小时）逐渐下降，具有明显的时间依赖性效应。这些随时间的曲折变化有助于更好地理解微囊藻毒素对鱼类造成的氧化应激。
