Baron Mira
Rapid Medical Research Inc., Cleveland, OH 44122, USA.
Postgrad Med. 2009 Mar;121(2):114-8. doi: 10.3810/pgm.2009.03.1971.
Viral respiratory tract infection is the most common illness among humans. Probiotics have been known to enhance the immune system and, therefore, may represent a significant therapeutic advancement for treating viral respiratory tract infections.
A controlled study was conducted to evaluate the effects of the patented GanedenBC30 probiotic (Bacillus coagulans GBI-30, 6086, marketed as Sustenex [Ganeden Biotech, Inc., Mayfield Heights, OH]) on the immune system when exposed to adenovirus and influenza in otherwise healthy adults.
Ten healthy men and women (average age, 44 years) were instructed to consume 1 capsule of GanedenBC30 with water once a day for 30 days. At baseline and after completion of the 30-day treatment, blood levels of cytokines were measured in vitro after T-cell exposure to adenovirus and influenza A. Each participant served as his/her own control with baseline blood draw.
The use of GanedenBC30 significantly increased T-cell production of TNF-alpha in response to adenovirus exposure (P = 0.027) and influenza A (H3N2 Texas strain) exposure (P = 0.004), but it did not have a significant effect on the response to other strains of influenza. No serious adverse events were reported throughout the study.
The patented GanedenBC30 probiotic may be a safe and effective therapeutic option for enhancing T-cell response to certain viral respiratory tract infections.
病毒性呼吸道感染是人类最常见的疾病。已知益生菌可增强免疫系统，因此可能是治疗病毒性呼吸道感染的一项重大治疗进展。
进行一项对照研究，以评估专利产品GanedenBC30益生菌（凝结芽孢杆菌GBI-30, 6086，商品名为Sustenex [Ganeden生物技术公司，俄亥俄州梅菲尔德高地]）对健康成年人接触腺病毒和流感病毒时免疫系统的影响。
10名健康男性和女性（平均年龄44岁）被指示每天用水服用1粒GanedenBC30胶囊，持续30天。在基线时以及30天治疗结束后，T细胞接触腺病毒和甲型流感病毒后，在体外测量细胞因子的血液水平。每位参与者以基线采血作为自身对照。
使用GanedenBC30可显著增加T细胞在接触腺病毒（P = 0.027）和甲型流感病毒（H3N2德克萨斯株）（P = 0.004）时肿瘤坏死因子-α的产生，但对其他流感毒株的反应没有显著影响。在整个研究过程中未报告严重不良事件。
专利产品GanedenBC30益生菌可能是增强T细胞对某些病毒性呼吸道感染反应的一种安全有效的治疗选择。
