Putney James W
Nat Cell Biol. 2009 Apr;11(4):381-2. doi: 10.1038/ncb0409-381.
Depletion of Ca(2+) from intracellular stores has long been known to signal to and activate plasma membrane 'store-operated' channels. We now learn that store depletion also controls the formation of cyclic AMP (cAMP) through the regulation of adenylyl cyclase (A-Cyclase). These findings substantially broaden the scope and biological significance of Ca(2+) store-regulated signalling.
长期以来，人们一直知道细胞内储存的Ca(2+)耗尽会向质膜“储存操纵”通道发出信号并激活该通道。我们现在了解到，储存耗尽还通过调节腺苷酸环化酶（A-环化酶）来控制环磷酸腺苷（cAMP）的形成。这些发现大大拓宽了Ca(2+)储存调节信号传导的范围和生物学意义。
