H3抗磷脂独特型见于系统性红斑狼疮（SLE）患者，而不见于梅毒患者。
The H3 anti-phospholipid idiotype is found in patients with systemic lupus erythematosus (SLE) but not in patients with syphilis.
作者信息
Hohmann A, Comacchio R, Boswarva V, Sutjita M, Bradley J
机构信息
Department of Clinical Immunology, Flinders Medical Centre, Bedford Park, Australia.
出版信息
Clin Exp Immunol. 1991 Nov;86(2):207-11. doi: 10.1111/j.1365-2249.1991.tb05797.x.
The human H3 idiotype, defined by a mouse monoclonal antibody S2.9, is commonly found in patients with SLE where it is correlated with the amount of anti-cardiolipin antibodies. No correlation between the amount of anti-cardiolipin antibody and the H3 idiotype is found in patients with syphilis. Using the S2.9 antibody, serum from each of 10 patients with SLE and eight patients with syphilis was separated into H3-bearing and H3-negative fractions. Comparison of the partition of anti-cardiolipin antibody in these two groups of patients revealed that much of the anti-cardiolipin antibody (44-91%) was found in the H3+ fraction in patients with SLE; in patients with syphilis, virtually none of the anti-cardiolipin antibody was H3+. In patients with SLE, the H3+ fraction contained both IgG and IgM and antibodies of both kappa and lambda light chains. The H3+ fraction was polyspecific and frequently reacted with dsDNA.
由小鼠单克隆抗体S2.9定义的人H3独特型，常见于系统性红斑狼疮（SLE）患者中，且与抗心磷脂抗体的量相关。在梅毒患者中未发现抗心磷脂抗体量与H3独特型之间存在相关性。使用S2.9抗体，将10例SLE患者和8例梅毒患者的血清分别分离为携带H3和H3阴性部分。比较这两组患者中抗心磷脂抗体的分布情况发现，在SLE患者中，大部分抗心磷脂抗体（44%-91%）存在于H3阳性部分；而在梅毒患者中，几乎没有抗心磷脂抗体是H3阳性的。在SLE患者中，H3阳性部分同时含有IgG和IgM以及κ和λ轻链的抗体。H3阳性部分具有多特异性，且经常与双链DNA发生反应。
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