系统性红斑狼疮患者中与DNA和心磷脂交叉反应的抗体。
Antibodies cross-reactive with DNA and cardiolipin in patients with systemic lupus erythematosus.
作者信息
Koike T, Tomioka H, Kumagai A
出版信息
Clin Exp Immunol. 1982 Nov;50(2):298-302.
Abstract
Using a modified solid phase radioimmunoassay (RIA), sera from 11 patients with systemic lupus erythematosus (SLE) that had high DNA binding activities were analysed for their ability to cross-react with phospholipids. Polyspecific anti-DNA antibodies that reacted with both ssDNA and dsDNA had the ability to cross-react with phospholipids, especially cardiolipin. The relationship between biological false-positive serological tests for syphilis (BFP-STS) and the magnitude of serum anti-DNA antibody levels is also discussed.
摘要
采用改良的固相放射免疫测定法（RIA），对11例具有高DNA结合活性的系统性红斑狼疮（SLE）患者的血清进行分析，以检测其与磷脂发生交叉反应的能力。能与单链DNA和双链DNA发生反应的多特异性抗DNA抗体具有与磷脂，尤其是心磷脂发生交叉反应的能力。文中还讨论了梅毒生物学假阳性血清试验（BFP-STS）与血清抗DNA抗体水平高低之间的关系。
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